Feed additive Flavomycin premix Powder

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Flavomycin premix Powder Usage and Synthesis.

Flavomycin is a phosphorylated polysaccharide antibiotic, and its antibacterial mechanism is to inhibit bacterial reproduction by interfering with the biosynthesis of peptidoglycan, which is a structural material of cell wall.

The growth-promoting principle of Flavomycin may lie in its ability to improve the digestion of energy and protein in the feed; to make the intestinal wall thinner so as to improve the absorption of nutrients; and to effectively maintain the balance of the intestinal flora and the stability of the rumen pH value.

Bacteria are not easy to produce resistance to Flavomycin, Flavomycin is not easy to produce cross-resistance with other antibiotics, Flavomycin has a narrow antibacterial spectrum, mainly effective for Gram-positive bacteria, and other antibiotic-resistant Gram-positive bacteria are also effective, but the role of Gram-negative bacteria is very weak.

Uses of Flavomycin premix.

It is very effective against gram-positive bacteria in the digestive tract of livestock and poultry. Can be used in chicken feed at a dosage of 1(100×104U)-5(500×104U) g/t; can be used in pig feed up to 2 months of age at a dosage of 10-25g/t; can be used in pig feed up to 4 months of age at a maximum dosage of 5g/t; and can also be used in beef cattle feed at a dosage of 30-50mg/(head- day).

Pharmacological Effect of Flavomycin premix.

1, Pharmacodynamics Flavomycin is a phosphorylated polysaccharide antibiotic, and its antibacterial mechanism is to inhibit bacterial reproduction by interfering with the biosynthesis of peptidoglycan, which is a structural material of cell wall.

The growth-promoting principle of Flavomycin may lie in its ability to improve the digestion of energy and protein in feed; to make the intestinal wall thinner so as to improve the absorption of nutrients; to effectively maintain the balance of intestinal flora and the stability of rumen pH.

Bacteria are not easy to produce resistance to Flavomycin, and Flavomycin is not easy to produce cross-resistance with other antibiotics. Flavomycin has a narrower antibacterial spectrum, mainly effective on Gram-positive bacteria, and also effective on other antibiotic-resistant Gram-positive bacteria, but very weak on Gram-negative bacteria.

It can thin the intestinal wall, improve digestion and absorption, promote the growth of livestock and poultry, improve the feed utilisation rate, and increase the remuneration of production performance; regulate the intestinal flora and PH value, and facilitate the decomposition of sugar and protein synthesis; increase the production of rumen sugar, promote the conversion of NPN into bacterial proteins, and reduce the content of ammonia and bacterial toxins; it is no longer clinically used as an antimicrobial.

2, Pharmacokinetics Flavomycin is almost not absorbed by the digestive tract after oral administration, and almost all of it is discharged from the faeces after 24h. Broilers 350 times the recommended dose, laying hens 25 times the recommended dose, pigs and beef cattle 16 times the recommended dose of mixed feeding, slaughtered in blood, muscle, liver, kidney, skin, fat and eggs are not detected residues of aflatoxin, cattle daily at a dose of 45mg for 370 days, no residues detected in milk.

3, Toxicology The toxicity of Flavomycin is very low, the LD50 of male mice is more than 10g/kg for internal administration and 1520mg/kg for intraperitoneal injection.

4, drug interactions Flavomycin and other antibiotics do not produce antagonistic effects, can be used with sulfonamides, tamoxifen, erythromycin, lincomycin and ion carrier anticoccidial drugs.

Production Methods of Flavomycin premix.

Fermented by Streptomyces griseus. Using glucose, soybean meal and salt as culture medium, deep fermentation culture, fermentation liquid by spray drying to get the product

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