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Rosemarinic acid has strong anti-inflammatory activity, at the same time rosemarinic acid also has antibacterial, antiviral, anti-tumour activity, and with the inhibition of acute and chronic infections, anti-ultraviolet light, inhibit the degradation of elastin and other properties has made rosemarinic acid become a cosmetic additive. At present, rosemarinic acid has demonstrated its important application value in the fields of pharmaceuticals, food and cosmetics.
In summary, rosemarinic acid has very broad application prospects and market value, the main application areas:
1. Food field: rosemarinic acid, as a natural high-efficiency antioxidant, can be used as a substitute for BHA and BHT in animal and vegetable fats and oils, dairy products, oil-rich foods, confectionery and baked foods; it can also be used as a spice for all kinds of soups and flavouring foods; and it has antiseptic and antibacterial effects.
In Japan, perilla extract, which is rich in rosemarinic acid, is used as a decoration to improve the shelf life of fresh seafood.
2. Health care field: anti-tumour, anti-hepatitis and protection against liver damage, anti-nephritis, anti-thrombosis and anti-platelet aggregation, etc., as well as refreshing the brain, enhance memory, improve nervousness and drowsiness and other effects.
3. Cosmetic field: used in skin care products can play a role in removing pigmentation, antioxidant, increase skin elasticity, delay aging, etc.; used in shampoo hair care products, can promote blood circulation of the scalp, improve hair loss, reduce the incidence of dandruff and stimulate the growth of hair, moisturise the hair.
Therefore, rosemarinic acid can be used as a good additive in cosmetics.
Characteristic of Rosmarinic Acid.
Stability: The stability of rosemarinic acid is good.
Salt and sucrose have no effect on the stability of rosmarinic acid; pH and temperature have less effect on the stability of rosmarinic acid, and the results show that rosmarinic acid is more suitable to be preserved and used in acidic and low-temperature conditions; light has a greater effect on rosmarinic acid, so it should be avoided as much as possible when using it; Ca2+, Mg2+ have a greater effect on the stability of rosmarinic acid, and the other metal ions have a smaller effect on it, and contact with calcium and magnesium should be avoided when using it; low concentration of sodium benzoate and potassium sorbate has a lesser effect on the stability of rosemary acid. Other metal ions have less effect on rosmarinic acid and should be avoided as much as possible when using it;
Low concentration of sodium benzoate, potassium sorbate on the stability of rosemarinic acid has a small impact, the use of food additives should be added in accordance with the hygiene standards for the use of appropriate amount; ascorbic acid has a certain effect on rosemarinic acid, low concentration of the impact of small; oxidising agent hydrogen peroxide on the impact of rosemarinic acid is large; reducing agent sodium metabisulphite on the impact of rosemarinic acid is small.
Pharmacological Effect Rosmarinic Acid.
1 Antioxidant effects
Rosmarinic acid has strong free radical scavenging activity and antioxidant effects.
Studies have shown that its mechanism of action is: rosemarinic acid and unsaturated fatty acids competitive and lipid peroxyl binding to end the chain reaction of lipid peroxidation, reduce the rate of lipid peroxidation, and rosemarinic acid is oxidised to quinone; rosemarinic acid can inhibit the respiratory outbreak of neutrophils and through the reduction of intracellular calcium concentration and inhibit the release of lysosomes; inhibition of endothelial cells regulate the oxidation of low-density lipoproteins.
The antioxidant effect of rosemarinic acid is related to its structure, and studies have shown that the o-diphenol hydroxyl group is the material basis for free radical scavenging activity. And the conjugated double bond at the C3 position has a potentiating effect.
2 Antidepressant effect
Rosmarinic acid has antidepressant effects on animal models of depression. In the mouse brain hippocampal gyrus cell proliferation experiments, with bromodeoxyuridine antibody for immunohistochemical analysis, to explore its mechanism of action, found that rosemarinic acid treatment group, the increase in labeled value-added cells, combined with the forced swimming test of the depression animal model, suggesting that rosemarinic acid, at least in part through the hippocampal gyrus neonatal cell proliferation and produce an antidepressant-like effect.
Product Method of Bulk Rosmarinic Acid Powder.
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