Natural Plant Extract Nattokinase Powder

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Nattokinase Powder Usage and Synthesis.

Natto is a traditional Japanese fermented soybean product made by fermenting and steaming soybeans at a certain temperature and humidity by the Bacillus natto bacteria, and it has been used as a main meal accompaniment for more than 2,000 years, and has been used for both medicinal and food purposes in folklore.

Mature natto is golden in colour, covered with a layer of sticky material, and has a long, silky texture when picked up. Natto has a unique flavour, is rich in nutrients and has a variety of health functions. It is known as a "super health food" and is very popular among the Japanese people.

At present, natto has become popular in Japan, Canada, the United States and some countries in Europe, a health food, our country also has enterprises began to produce and sell.

During the fermentation process of natto, natto bacteria produce a serine protease (Natto Kinase), which was first discovered in 1987 by Yoko Sumi of Miyazaki Medical University.

Uses and functions of Nattokinase.

In view of the miraculous function of nattokinase, many scholars at home and abroad have carried out in-depth development of natto food and health food containing nattokinase, and opened up the market all over the world as a kind of functional food that can treat and prevent cardio-cerebral thrombosis, coronary heart disease, angina pectoris, stroke, dementia, and a variety of common and frequent diseases.

1. In the international market, the largest producer of nattokinase products is Japan, where a number of companies have launched products containing nattokinase as the main ingredient and have set up sales and service organisations around the world.

According to the literature, Japan consumes 220,000 tonnes of natto annually, which is about 160 billion yen, and there are more than 400 factories producing natto and nattokinase products for domestic and international supply.

2. Domestically, at present, the Nattokinase preparation - Nkai capsule developed by the Institute of Applied Microbiology of Heilongjiang Academy of Sciences is in the pilot stage.

As for domestic enterprises, there are Beijing Yanjing Zhongfa's Yanjing brand natto, Beijing Longxing's natto capsules, Tianjin Baidu's natto chewable tablets and Hunan Guishengfang's nattokin capsules.

Measurement methods of Nattokinase.

At present, the commonly used methods for the determination of nattokinase activity at home and abroad mainly include: agarose-fibrin plate method, fibrin block dissolution time method, tetrapeptide substrate method, serum plate method and so on.

Such as agarose-fibrin plate method: fibrin plate method is one of the earliest methods used for the determination of nattokinase activity, which uses the standard urokinase, fibrinolytic enzyme, etc. as the standard control to draw a standard curve, and reads the enzyme activity of the sample from the standard curve.

The principle of its determination is that agarose, fibrinogen and thrombin are mixed in a certain proportion, and the cross-linked fibrin generated is the substrate, and the enzyme activity is linearly related to the area of the dissolution circle.

Therefore, the fibrinolytic activity of nattokinase is expressed in terms of the area of the dissolution circle.

Product Method of Bulk Nattokinase Powder.

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