Natural Panax Notoginseng Extract Powder

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Panax Notoginseng Extract Powder Usage and Synthesis.

Panax quinquefolium extract is the extract of the root of Panax quinquefolium, a plant of the genus Ginseng of the family Wujiaceae, mainly containing saponins, with the effect of dispersing blood stasis and stopping haematochezia, subduing swellings and fixing pain, it is used for haemoptysis, vomiting blood, epistaxis, haemostasis, leakage, bleeding from traumatic injuries, thoracic and abdominal stabbing pain, and bruises and pounds.

Uses and functions of Panax Notoginseng Extract.

Dispersing blood stasis and stopping bleeding, subduing swelling and relieving pain. Used for haemoptysis, vomiting blood, epistaxis, haematochezia, leakage, bleeding from trauma, stabbing pain in chest and abdomen, bruises and injuries. 3~9g, powdered and swallowed, 1~3g at a time.

Pharmacological Effect of Panax Notoginseng Extract Powder.

Effects on blood and haematopoietic system: Panax ginseng has strong haemostatic, anti-platelet aggregation and thrombolytic, haemolytic and haematopoietic effects.

Anti-inflammatory effects: The aqueous extract of Panax ginseng root, 50~200mg/kg subcutaneously, can inhibit the increase of skin vascular permeability caused by hyaluronidase, chondroitinase ABC, α-chymotrypsin and histamine by 11%~36%.

Total saponin of Panax ginseng root, inhibited the ankle joint swelling and foot swelling induced by keratine gum, kaolin, 5-hydroxytryptamine, egg white and hyaluronidase in mice or rats. In addition, the total saponin of Panax ginseng has obvious inhibitory effect on the swelling of mouse auricle caused by xylene and croton oil.

Effects on immune function: Panax ginseng total saponin 160mg/kg can increase the number of haemolytic vacuoles in mice by 92%, and can also increase the phagocytosis rate and phagocytosis index of abdominal macrophages in mice. It can significantly increase the phagocytosis rate of rat alveolar macrophages, increase the total number of leukocytes and the percentage of lymphocytes in blood, and reduce the leukocyte migration index.

Antioxidant and anti-aging effects: Panax notoginseng saponins have a certain elimination of O2- effect, stronger than ginseng saponins and gibberellic acid saponins.

Panax ginseng powder pulp 200mg/kg given to rats by gavage for 4 weeks can make the content of lipid peroxides (LPO) in the blood significantly reduced. Among the tissues, only the reduction of LPO in brain tissue was very significant. After the administration of Panax ginseng, there was a tendency for the SOD activity in the blood of rats to be elevated, but there was no significant difference.

In the homogenates of the tissues measured, only the brain tissue showed a significant elevation of SOD activity, while all other tissues showed no significant changes.

Panax ginseng and stem and leaf saponins can also prolong the average life span of Drosophila, improve its ability to fly, reduce the content of lipofuscin in the head, inhibit the production of LPO in external and internal tissues of mice and increase the activity of SOD in blood and brain tissues of mice.

It suggests that Panax ginseng has the effect of prolonging life span and enhancing the vitality of the organism.

Its anti-aging mechanism may be related to directly reducing the formation of free radicals, inhibiting lipid peroxidation and activating SOD activity in vivo, thus accelerating free radical scavenging and reducing the damage of free radicals to the structure and function of the organism.

Extraction Processes of Bulk Panax Notoginseng Extract Powder.

Percolation method: Panax pseudoginseng is crushed into coarse powder (20-40 mesh), soaked in 75% ethanol for 12h, then slowly percolated at a rate of about 2mL/kg-min-1, and the percolating solution equivalent to the selected amount of Panax pseudoginseng is collected and concentrated and vacuum-dried under reduced pressure.

Hot immersion method: Panax pseudoginseng was crushed into coarse powder (20-40 mesh), soaked in 75% ethanol for 12h, hot immersion at 60°C for 3 times, each time the immersion time is about lh, collect and merge the filtrate, concentrated under reduced pressure, vacuum drying.

Thermal reflux method: Panax pseudoginseng was crushed into coarse powder (20-40 mesh), added with 75% ethanol, soaked for about 12h, ultrasonication for 30min for 3 times, filtered, collected and combined filtrate, concentrated under reduced pressure and vacuum dried.

Ultrasonic extraction method: Panax notoginseng crushed into coarse powder (20-40 mesh), add 75% ethanol, soak about 12h, ultrasonic 30min, a total of 3 times, filtered, collect the combined filtrate, concentrated under reduced pressure, vacuum drying.

The extraction effect of reflux method and percolation method was almost the same, and both processes were feasible. However, due to the possibility of destruction of Panax notoginseng saponins by heat, and the easier operation of percolation method in the production practice, the extraction process of Panax notoginseng was better than percolation method.

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