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Hesperidin and hesperidinolide are coumarin-like constituents of the Chinese medicine Qinpi, a constituent for the treatment of dysentery.
Uses of Radix Notoginseng Extract.
Panax ginseng leaves can dissipate blood stasis and stop bleeding, and have good curative effects on trauma and bleeding, bruises and swelling, carbuncle and sores.
The total saponin contained in Panax ginseng leaves has sedative effect, which can inhibit the nervous system and make the pain sensory nerves insensitive, so it has analgesic effect.
Panax ginseng leaves total saponins can varying degrees of anti-bradykinin, histamine, 5-HT caused by increased capillary permeability, but also on the croton oil or xylene caused by inflammation has a significant inhibitory effect.
It can elevate the level of cyclic adenosine monophosphate in neutrophils due to inflammation, inhibit the elevation of tumour necrosis factor and nitric oxide content, and reduce the level of calcium ions in neutrophils, thus inhibiting the function of neutrophils.
Total saponins of Panax ginseng stem and leaves can inhibit malondialdehyde production and increase superoxide dismutase activity in order to scavenge free radicals, which has the effect of delaying aging.
Pharmacological Effect of Radix Notoginseng Extract.
Effects on the central nervous system Panax notoginseng leaves total saponin 100mg/kg, 200mg/kg intraperitoneal injection, can significantly Significantly reduced the voluntary activity of mice, significantly prolonged the time to the subthreshold dose of sodium pentobarbital and chloral hydrate synergistic eye sleep.
It can also significantly enhance the inhibitory effect of chlorpromazine on the voluntary activity of mice. It can also counteract the excitatory effects of amphetamine and sodium benzoate caffeine on voluntary activity in mice.
Panax ginseng leaf saponins can also reduce the frequency of seizures induced by pentylenetetrazol in mice and delay the time of death of Tu-Ti-Ning seizure. The total saponins of Panax quinquefolium showed obvious inhibitory effect on the central nervous system.
Panax ginseng leaves total saponin 100mg/kg, 200mg/kg intraperitoneal injection can significantly reduce the number of acetic acid-induced writhing in mice, and can significantly improve the pain threshold of thermal stimulation in mice.
Pharmacological Effect of Radix Notoginseng Extract.
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