Chrysophanic acid Powder CAS 481-74-3

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Chrysophanic acid Usage and Synthesis.

Chrysophanol is an organic compound with the formula C15H10O4. It has antibacterial effect on a variety of bacteria, can stop cough, promote bowel movement, promote nerve excitation and muscle paralysis, and also has obvious inhibitory effect on melanoma in mice.

What are the benefits of chrysophanol?

Chrysophanol has demonstrated significant potential in cancer prevention (Fig. 1). Research indicates that it can inhibit the proliferation and survival of various cancer cells through multiple mechanisms including blocking the cell cycle, inducing apoptosis, and regulating autophagy.

Uses of Chrysophanic acid.

Chrysophanic Acid has antibacterial effect on a variety of bacteria, can relieve cough, promote intestinal movement, promote nerve excitation and muscle paralysis, and also has obvious inhibitory effect on melanoma in mice.

What is the mechanism of action of chrysophanol?

Mechanism of action

Chrysophanol can increase osteoblast differentiation by inducing AMP-activated protein kinase as well as Smad1/5/9. Chrysophanol acts to improve renal interstitial fibrosis by downregulating TGF-β1 and phospho-Smad3 and by upregulating Smad7.

Chrysophanic Acid in Traditional Medicine Systems

Chrysophanic Acid has a long history of use in traditional medicine:

Traditional Chinese Medicine (TCM): Rhubarb root (Da Huang), containing Chrysophanic Acid, has been used for centuries in TCM for its purgative and anti-inflammatory properties.

Ayurvedic Medicine: Senna leaves and pods, containing Chrysophanic Acid derivatives, have been traditionally used for their laxative effects.

Folk Medicine Practices: Various cultures have used plants containing Chrysophanic Acid topically for skin conditions and internally for digestive issues.

Pharmacological action of Chrysophanic acid.

Chrysophanic Acid has obvious antitussive effect. It has various inhibitory effects on A streptococcus, pneumococcus, influenza bacillus and catarrcoccus. Can promote bowel movement, and can promote nerve excitation and muscle paralysis. Oral or subcutaneous injection can significantly shorten the blood clotting time. Rat test proved that this product has diuretic effect.

What are the sources of chrysophanol?

Two genera, Rumex and Rheum, belonging to Polygonaceae are the main sources of chrysophanol, which dominantly occurs in the roots and rhizomes of these plants [23,24]. The presence of chrysophanol has also been documented in the bark of some species of Rhamnus, a member of Rhamnaceae

How to Choose a Quality Chrysophanic Acid Product

When selecting a Chrysophanic Acid product, consider:

Source and Purity: Look for products that specify the plant source and extraction method.

Concentration: Effective topical products typically contain between 0.5% to 2% Chrysophanic Acid.

Third-Party Testing: Choose brands that provide certificates of analysis from independent laboratories.

Additional Ingredients: Consider the formulation and whether complementary ingredients enhance the desired effects.

Brand Reputation: Select products from companies with transparency about sourcing and manufacturing practices.

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