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Dl-selenomethionine, as a natural organic selenium source in living organisms, is gradually replacing inorganic compounds such as sodium selenite and becoming a good source of selenium supplement and an intermediate for the preparation of other selenium-containing drugs, and has become the focus of the development of selenium compounds.
Uses of selenomethionine.
Dl-selenomethionine, as a natural organic selenium source in living organisms, is gradually replacing inorganic compounds such as sodium selenite and becoming a good source of selenium supplement and an intermediate for the preparation of other selenium-containing drugs, and has become the focus of the development of selenium compounds.
Dl-selenometionine is a selenium-containing amino acid in which the S of methionine is replaced by Se, which plays an important role in maintaining the physiological function of the human body and preventing and treating some diseases. The application of DL-selenomethionine and its innovative compounds in various fields of life science is increasingly extensive, especially in the prevention and treatment of diabetes mellitus. It is found that DL-selenomethionine is one of the existing forms of organic selenium in artificially produced selenium-rich natural food.
The production of these selenium-rich natural foods is often limited by conditions, but the synthesis of selenomethionine by chemical method is not limited by natural strips, which is an effective way to produce selenium-supplementing products. Dl-selenomethionine is widely used in food, beverage, health care products, treatment of gastrointestinal diseases, treatment of diabetes and Alzheimer's disease because of its unique biological effects such as high antioxidant, low toxicity and high absorption and utilization.
Pharmacological action of selenomethionine.
Product Method of Bulk selenomethionine Powder.
Synthesis of DL-Selenomethionine sodium salt crude: The alcohol solvent containing alkali metal carbonate is used as the reduction reaction medium. The alcohol solvent containing alkali metal carbonate refers to one or several combinations of methanol, ethanol, propanol, isopropanol and butanol containing potassium carbonate or/and sodium carbonate. Step (2) purified dimethyl diselenol reacts with hydrazine hydrate and catalyst at a temperature of 5 ~ 15℃ for 0.5 ~ 2h to generate sodium methelenol. The molar ratio of hydrazine hydrate and dimethyl diselenide is 1 ~ 2, and then sodium methelenol and α-amino-gamma-butylactone hydrobromide with molar ratio of 1 ~ 1.5 of sodium methelenol are heated to 60 ~ 65℃ for reflux reaction for 6h, and the water with molar ratio of 0.5 ~ 500 of DL-selenomethionine is added for hydrolysis, and the pH value is adjusted 5 ~ 6. Dl-selenomethionine sodium salt crude product is obtained by dehydration, wherein the catalyst comprises carbon powder and/or ferric chloride, and the molar ratio with dimethyl diselenether is 0.05 ~ 0.1;
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