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Olanzapine, a new atypical neuroleptic agent, can bind to dopamine receptors, 5-HT receptors and cholinergic receptors, and has antagonistic effects. Antagonistic D2 receptors are associated with positive symptoms in the treatment of schizophrenia; Antagonism of the 5-HT2A receptor is associated with negative symptoms of treatment for schizophrenia. Unlike clozapine, this product does not develop granulocyte deficiency, delay disorder and severe depressive symptoms. Oral absorption is good, food has no effect on its absorption rate, and the plasma peak concentration can be reached 5 to 8 hours after oral administration. Mainly metabolized in the liver, about 75% of this product is excreted from the urine in the form of metabolites.
Uses of Olanzapine.
For the acute phase and maintenance treatment of schizophrenia and other psychiatric disorders with severe positive and/or negative symptoms; It can also relieve secondary emotional symptoms common in schizophrenia and related diseases.
Drug interaction of Olanzapine.
Product Method of Bulk Olanzapine Powder.
Olanzapine was obtained by reflux of 4-amino-2-methyl-10h-thiophene [2, 3-b][1,5] benzodiazepine leather hydrochloride and n-methylpiperazine in dimethyl sulfoxide and toluene under nitrogen protection for 20h.
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