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Fedamicin and its major metabolite, OP-1118, are substrates for P-glycoprotein efflux transporters, which are present in the GI tract. The interactions of fedamicin with P-glycoprotein substrates and their inhibitors, as well as with CYP450 isoenzymes 3A4, 2C9, and 2C19 have been evaluated. The drugs studied included cyclosporin, digoxin, midazolam, omeprazole and warfarin. Although the combination of cyclosporine and fedamicin nearly tripled the maximum blood concentration of fedamicin, these changes were not clinically significant because the concentration was still in the ng/mL range. There was no change in the pharmacokinetics of fedamicin in combination with the other drugs. According to current research, fedamicin does not need to be adjusted when drugs that alter P-glycoprotein efflux transporters and cytochrome P450 isoenzymes are used simultaneously.
Uses of Fidaxomicin.
In vitro study of Fidaxomicin.
Fidaxomicin inhibits RNA polymerase by binding to the DNA template-RNA polymerase (RNAP) complex before the open RNAP-DNA complex is formed, that is, before transcription begins. As a result, it inhibits protein synthesis. As a result, apoptosis is triggered in susceptible organisms such as C.difficile.
Product Methods of Bulk Fidaxomicin powder.
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