Pharmaceuticals Celecoxib Raw Materials Powder

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Celecoxib Powder Usage and Synthesis.

Celeroxib capsule is a class of non-steroidal anti-inflammatory drugs (NSAIDs) commonly used in clinic. It mainly inhibits the activity of cyclooxygenase-2 (COX-2), inhibits the synthesis of prostaglandins, and reduces the edema and pain of local tissues. Then play analgesic, anti-inflammatory, antipyretic role.

Uses and functions of Celecoxib.

1) Used to relieve the signs and symptoms of osteoarthritis.

2) Used to relieve the signs and symptoms of rheumatoid arthritis in adults.

3) For the treatment of acute pain in adults

Pharmacological action of Celecoxib.

Celecoxib has anti-inflammatory and analgesic effects of NSAIDs. Due to the characteristics of its chemical structure, this product can be combined with COX-2 and has a selective inhibition effect on COX-2. The phenyl group of celeoxib binds to the hydrophobic channel of COX-2, and the hydrophilic sulfa group forms hydrogen chains with the 513 arginine and 90 histidine in the "side pocket" of COX-2. In addition, this product is closely combined with arginine at the position of COX-2120, and plays a role in inhibiting the conversion of COX-2 to arachidonic acid into prostaglandins, which is harmful to human body. Due to the subtle difference in the structure of COX-1 and COX-2, this drug cannot enter the molecule of COX-1, nor can it inhibit the conversion of COX-1 to arachidonic acid into prostaglandins. Therefore, this product has good anti-inflammatory and analgesic effects, protect gastric mucosa, maintain renal blood flow, regulate platelet aggregation, and solve the digestive tract irritation of commonly used NSAIDs.

Product method of Bulk Celecoxib Powder.

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