Mitiglinide Calcium raw material Powder

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Mitiglinide Calcium powder Usage and Synthesis.

Miglinide can close K+-ATP channels on islet beta cells, increase intracellular Ca2+ concentration, and degranulate extracellular insulin-containing vesicles, thus stimulating insulin secretion. In vitro experiments show that calcium miglinide can stimulate the secretion of insulin from isolated hamster islet cells. Electrophysiological studies have shown that this product can inhibit the opening degree of ATP-sensitive K+ channel, and at the concentration of 10μmol/L, this channel can be completely blocked and Ca2+ can be stimulated to enter cells. In the presence of glucose, calcium miglinide can dose-dependently stimulate insulin secretion from rat isolated and isolated perfused pancreas.

Uses of Mitiglinide Calcium.

Both miglinide and nateglinide are fast-acting insulin secreting agents, but miglinide shows a more significant improvement in postpranational hyperglycemia. The effect of miglinide on insulin secretion in HIT-T15 cells is about 100 times greater than that of nateglinide, and the effect on insulin secretion in type 2 diabetic animals is more significant than that of nateglinide. Clinical trials have shown that this class of drugs is superior to other hypoglycemic drugs so far in terms of efficacy and safety, and is a new type of fast-acting "meal blood glucose regulator" that promotes insulin secretion by islet cells. It is suitable for type 2 diabetes patients who cannot effectively control hyperglycemia through diet and exercise therapy, mainly for controlling postprandial hyperglycemia.

Drug combination of Mitiglinide Calcium.

Product Methods of Mitiglinide Calcium.

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