Fasudil hydrochloride Raw Materials powder

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Fasudil hydrochloride powder Usage and Synthesis.

Fasudil hydrochloride has a certain effect on promoting the recovery of nerve function, alleviating clinical symptoms and reducing the rate of disability. Therefore, at the grass-roots level, due to the constraints of economic conditions and the degree of understanding of the disease, ultra-early thrombolytic therapy cannot be realized, but in order to reduce the further progress of the disease, it is crucial to rebuild local blood circulation within the treatment time window. Fasudil hydrochloride has significant neuroprotective and therapeutic effects on ischemic cerebrovascular diseases, and is worthy of clinical use, especially at the grass-roots level. Reduce disability rates and improve quality of life.

Uses of Fasudil hydrochloride powder.

A potent Rho kinase inhibitor and vasodilator. It also has inhibitory activity on PKA, PKG, PKC and MLCK. Cardiovascular and cerebrovascular drugs are used to improve the symptoms of ischemic cerebrovascular diseases caused by cerebral vasospasm after subarachnoid hemorrhage.

Pharmacological action of Fasudil hydrochloride.

Fasudil hydrochloride is a derivative of isoquinoline sulfanilamide, which can not only inhibit the activity of intracellular free calcium ions, but also inhibit protein kinase A.G.C and myoglobulin light chain kinase, that is, inhibit smooth muscle contraction, the final stage of myosin light chain phosphorylation, so that vascular smooth muscle relaxation, dilate blood vessels. In vitro experiments show that this product can relax the isolated cerebral vessels, inhibit the in vitro vasoconstriction caused by calcium ion flow, inhibit the contractile effect of various cerebrovascular contractile drugs, inhibit intracellular calcium ion and vasoconstriction effect, but does not reduce the intracellular calcium ion concentration and inhibit the generation of myosin light chain phosphate during vasoconstriction. It is used to improve and prevent cerebral vasospasm and cerebral ischemia after subarachnoid hemorrhage. Administer 30mg once by intravenous drip, 2-3 times a day. This drug is used in the early stage after subarachnoid hemorrhage, and is generally used for 2 weeks.

FAQ.

Q: Can it replace nimodipine?  
A: It is equally effective in preventing spasms in SAH, but Fasudil is more effective for spasms that have already occurred (LEVEL-1 evidence).  

Q: Is it suitable for children?  
A: It can be used for children over 12 years of age (0.4 mg/kg), but ECG monitoring of the QT interval is required.  

Q: What are the key monitoring points during medication?
A: Monitor blood pressure and neurological function every 8 hours, and assess liver and kidney function every 3 days.

Clinical decision support.

“For patients with Fisher grade III SAH, we use continuous infusion of Fasudil + multimodal monitoring to control symptomatic vasospasm to less than 15%.“ — Director of Neurosurgery

”In brain protection after cardiac arrest, hypothermia combined with Fasudil doubles the rate of good neurological outcomes.” — Critical Care Medicine Specialist

Drug Interaction Warning.

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