Pharmaceutical material and intermeidates Felodipine

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Felodipine Powder Usage and Synthesis.

The mechanism of the action of felodipine is mainly two aspects: (1) it can reduce the systemic blood pressure; ② It can make the glomerular entry arteriole get sustained expansion. Therefore, felodipine can increase renal blood flow and glomerular filtration rate, improve the condition of renal ischemia, and prevent the disorder of renal vessel and glomerular structure and function. In addition, by regulating the passage of macromolecular substances through the glomerular basement membrane, the metabolic activity of residual kidney tissue can be reduced to a certain extent, and the formation of free radicals can be reduced to protect the kidneys. However, the disadvantage of felodipine is that kidney disease is significantly delayed in patients with kidney disease and a large amount of proteinuria. The main effect of felodipine is to reduce the systolic blood pressure and pulse pressure, and improve the endothelial function of blood vessels. To the point of anti-atherosclerosis.

Uses of Felodipine.

Used to treat high blood pressure. It is a selective calcium ion antagonist, which mainly inhibits the intracellular calcium flow of arteriole smooth muscle, selectively dilates arteriole, has no effect on veins, and does not cause postural hypotension; There was no obvious inhibitory effect on myocardium. While reducing the renal vascular resistance, this product does not affect the glomerular filtration rate and creatinine clearance rate, the renal blood flow does not change or even slightly increase, and has the effect of promoting sodium excretion and diuresis. This product can increase output and cardiac index, significantly reduce afterload, but has no significant effect on cardiac systolic function, preload and heart rate.

Pharmacological action of Felodipine.

Product Method of Bulk Felodipine Powder.

2, 3-dichlorobenzaldehyde, 3-aminobutyrate methyl ester and ethyl acetoacetate were reflow in isopropyl alcohol to obtain filodipine. Or 2, 3-dichlorobenzaldehyde condensates with methyl acetoacetate and ethyl 3-aminobutyrate to form felodipine.

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