Natural Domperidone raw Materials Powder

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Domperidone Powder Usage and Synthesis.

1. Symptoms of dyspepsia caused by delayed gastric emptying, gastroesophageal reflux, chronic gastritis, and esophagitis, including nausea, vomiting, belching, epigastric bloating, abdominal pain, and abdominal distension, as well as a burning sensation in the mouth and stomach caused by reflux.

2. Parkinson's disease, nausea and vomiting caused by various causes, such as functional, infectious, dietary, radiation therapy or drug therapy, and dopamine receptor agonists (such as levodopa, bromothalamine) treatment.

3, suitable for migraine, dysmenorrhea, craniocerebral trauma and intracranial lesions, radiation therapy and levodopa, non-steroidal anti-inflammatory drugs caused by nausea, vomiting.

4, it is also effective for nausea and vomiting caused by various organic or functional gastrointestinal disorders in the elderly.

5, domperidone is not effective for postoperative or vomiting caused by anesthesia or chemotherapy.

Uses of Domperidone.

Domperidone is a benimidazole compound with strong gastric motility and antiemetic effect, which can strengthen the tension of the lower esophageal sphincter, prevent gastroesophageal reflux, enhance gastric peristalsis, promote gastric emptance, coordinate gastric and duodenal motility, inhibit nausea and vomiting, effectively prevent bile regurgitation and do not affect gastric secretion. This product is a peripheral dopamine receptor antagonist, which directly blocks the dopamine receptor in the gastrointestinal tract and shows gastric motility. It can enhance esophageal peristalsis and lower esophageal sphincter tension. Due to its poor permeability to the blood-brain barrier, it has almost no antagonistic effect on dopamine receptors in the brain, so it can rule out mental and central nervous side effects.

In vitro study of Domperidone.

Product Method of Bulk Domperidone Powder.

2-nitro-1, 4-dichlorobenzene reacts with 4-aminocyclohexane carboxylic acid ethyl ester, rehydrogenated reduction, cyclization with urea, hydrolysis, to obtain 5-chloro-1 -(piperidine-4-yl)-1, 3-dihydro-2h-benzimidazole-2-ketone. Hydroxypropylamine nucleophilic substitution of chlorine in 2-nitrochlorobenzene, rehydrogenated reduction of nitro group to amino group, and then chlorinated with potassium cyanide, to obtain 1-(3-chloropropyl)-2, 3-dihydro-1h-benzimidazole-2-one. The two benzimidazole derivatives obtained above are performed as follows to obtain domperidone. 2.3 parts 1-(3-chloropropyl)-2, 3-dihydro-1h-benzimidazole-2-one, 2.5 parts 5-chloro-L -(piperidine-4-yl)-1, 3-dihydro-2h-benzimidazole-2-one, 3.2 parts sodium carbonate, 0.1 parts potassium iodide and 80 parts 4-methyl-2-pentanone were stirred together, and the reflux was 24h. Cool to room temperature and add water. The insoluble matter was filtered out and chromatography was carried out with silica gel column. The developed liquid was a mixture of chloroform and 10% methanol. Collect the effluent containing the product and concentrate it. The remainder was crystallized with 4-methyl-2-pentanone. After filtration, it is recrystallized with a mixture of dimethylformamide and water. 1.3 parts domperidone was obtained with a yield of 30% and a melting point of 242.5℃.

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