Nitrendipine raw Materials Powder

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Drug interaction of Nitrendipine Powder.

(1) It can increase the plasma concentration of digitalis, such as digoxin, by about 45% on average.

(2) beta-blocker: the vast majority of patients with the combination of this drug can strengthen the antihypertensive effect, and can reduce the tachycardia occurred after the product antihypertensive; However, individual patients may induce and aggravate systemic hypotension, heart failure, and angina pectoris.

(3) The combination of angiotensin-converting enzyme inhibitors was well tolerated and the antihypertensive effect was enhanced.

(4) Cimetidine can mediate the inhibition of liver cytochrome P450 enzyme, so that the first pass effect of nirendipine can be changed, and it is recommended to pay attention to the adjustment of drug dosage for patients who are taking cimetidine treatment with nirendipine.

Uses of Nitrendipine.

The second generation calcium antagonist is an ideal drug for the treatment of hypertension. It has significant and lasting antihypertensive and vasoconstrictive effects. It is suitable for various types of hypertension, such as primary and secondary mild and moderate hypertension, and can also be used for coronary heart disease, congestive heart failure and so on.

Pharmacological action of Nitrendipine.

Nitrendipine is used to treat hypertension, congestive heart failure, and hypertension with angina. It can selectively act on the calcium channels of vascular smooth muscle, inhibit the transmembrane calcium ion flow between vascular smooth muscle and myocardium, and has a greater affinity for blood vessels than myocardium, and a stronger selective effect on coronary arteries. The order of artery dilation intensity is coronary artery > femoral artery > renal artery > pulmonary artery. It can reduce myocardial oxygen consumption and protect ischemic myocardium. It can reduce total peripheral resistance and lower blood pressure.

Product Method of Bulk Nitrendipine Powder.

The acid catalyzed condensation of m-nitrobenzaldehyde and ethyl acetoacetate gives 2-(3-nitrobenzylidene) ethyl acetoacetate. 2-(3-nitrobenzyl) ethyl acetoacetate and 3-aminobutyrate methyl ester were placed in Soxlet extractor flask, anhydrous ethanol was added, and the siphon of Soxlet extractor was filled with filter paper wrapped molecular sieve, and then placed overnight after being heated in a water bath and refluxed for 4h. The crystallization was recrystallized with 5 times the amount of anhydrous ethanol to obtain Nitrendipine pure product with melting point of 158 ~ 159℃ and yield of 90.8%. Without molecular sieve, the yield was 86.1%.

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