Azelastine CAS 58581-89-8 Powder Raw Materials

CAS: 58581-89-8

MF: C22H24ClN3O

Specification​: 99% min Azelastine

Sample:  Azelastine Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Azelastine Powder Usage and Synthesis:

Azelastine Powder Raw Materials is white crystalline powder, odorless, bitter taste, easily soluble in chloroform, dichloromethane and glacial acetic acid, slightly soluble in methanol, slightly soluble in water or ethanol, insoluble in acetone and ether. The melting point is 225-229°C. Azelastine hydrochloride tablet is an anti-allergic drug, its main active ingredient is azelastine hydrochloride, azelastine hydrochloride and its main metabolite are antagonists of histamine H1 receptors. Histamine is a substance closely related to allergic reactions in the body. Azelastine hydrochloride and its metabolites mainly inhibit histamine, thereby having anti-allergic effects. Clinically, azelastine hydrochloride tablets are mainly used for anti-allergy. It can be used for allergic rhinitis, and can improve patients' symptoms related to allergic rhinitis, sneezing, runny nose, and nasal congestion. In addition, it can also be used for allergic reactions of the skin, such as acute and chronic urticaria. When using this drug, you need to pay attention to it. Since this drug may cause side effects of drowsiness, dizziness, and drowsiness, it is not suitable for patients to drive vehicles, operate machines, or work at heights that require concentration. drinking. In short, azelastine hydrochloride tablets are an antiallergic drug, which is mainly used for allergic rhinitis and skin allergic diseases.

Pharmacokinetics of Azelastine Powder:

Azelastine is commonly used in the form of nasal spray and tablet. For H1 receptor antagonists, anti-allergic drugs. For the treatment of allergic seasonal rhinitis and allergic perennial rhinitis, such as nasal discharge, sneezing and nasal itching. Azelastine hydrochloride and its major metabolites are histamine H1 receptor antagonists with Antihistamine and antiallergic effects. There are few pharmacokinetic studies of azelastine nasal administration.

Clinical Application of Azelastine Powder:

Azelastine hydrochloride tablet is an anti-allergic drug, which is mainly used in the treatment of allergic rhinitis in the department of otolaryngology. There are few oral azelastine hydrochloride tablets for clinical use. This kind of medicine needs to be taken twice a day, and it is not recommended for children under the age of twelve. Cetirizine, loratadine tablets, etc. are commonly used. Oral anti-allergic drugs are more, usually just take one tablet every night before going to bed. Azelastine hydrochloride nasal spray has more clinical applications, and it can be used together with steroid nasal sprays, and the effect is more significant.

Azelastine Powder Raw Materials can be made into drugs with the following properties:

Azelastine Hydrochloride Nasal Spray: Colorless transparent liquid, press the valve, and the liquid sprays out in the form of mist.

Azelastine Hydrochloride Tablets: white film-coated tablets, white after removing the film coat.

The specifications are as follows:

Azelastine hydrochloride nasal spray: 10ml: 10mg, 70 sprays, 0.14mg per spray; 10ml: 10mg, 100 sprays, 0.07mg per spray.

Azelastine hydrochloride tablets: 1mg; 2mg.