Desloratadine CAS 100643-71-8 Powder Raw Materials

CAS: 100643-71-8

MF: C19H19ClN2

Specification​: 99% min Desloratadine

Sample:  Desloratadine Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Desloratadine Powder Usage and Synthesis:

Desloratadine Powder has affinity and selectivity for peripheral H1 receptors, and is a new drug for the treatment of seasonal allergic rhinitis and chronic urticaria. Desloratadine is an Antihistamine. Common dosage forms include tablets, capsules, dispersible tablets, syrups, dry suspensions, etc. For the rapid relief of symptoms associated with allergic rhinitis, such as sneezing, runny nose and itchy nose, nasal congestion, nasal congestion; and itchy, watery and congested eyes; itchy palate and cough; also for the relief of chronic idiopathic urticaria associated symptoms such as itching, and can reduce the number and size of hives. Desloratadine Powder is the active metabolite of loratadine deformed in vivo. Desloratadine Raw Materials is the raw material of the new third-generation antihistamines, with strong anti-allergic effect, fast onset and long-lasting effect. Its antagonistic activity is loratadine It is 50 to 200 times that of Ding, Fexofenadine or Cetirizine, and it is safe and effective, well tolerated by patients, and its half-life is 21 to 24 hours, so it only needs to be taken once a day. Respiratory system and anti-allergic drugs.

Pharmacokinetics of Desloratadine Powder:

Desloratadine is a non-sedating long-acting tricyclic antihistamine, which is an active metabolite of loratadine, and can relieve allergic rhinitis or chronic idiopathic rhinitis by selectively antagonizing peripheral H1 receptors. Symptoms associated with urticaria. In addition, the results of in vitro studies show that this product can inhibit the release of histamine from human mast cells. Animal studies suggest that this product does not easily pass through the blood-brain barrier.

1. No cardiotoxicity

2. No central sedative effect

3. Few drug interactions

4. Good safety for patients with liver and kidney insufficiency

5. No food taboos

Clinical Application of Desloratadine Powder:

1. Strong anti-allergic effect Desloratadine specifically binds to H1 receptors with high selectivity. Among the currently known antihistamines, it has the strongest binding ability to H1 receptors and has significant anti-H1 receptors. body function. Desloratadine inhibited the release of inflammatory cytokines from stimulated human mast cells and basophils at nanomolar levels, and this inhibitory effect was stronger than that of dexamethasone and cetirizine.

2. Quick onset and long-lasting effect. Desloratadine itself is active and well absorbed. The onset time is less than 30 minutes. The maximum blood concentration is reached about 3 hours after oral administration. A clinical study on the onset time of patients with allergic rhinitis has proved that desloratadine has a faster onset than the existing antihistamines, and its average onset The time was 28.45min, while that of loratadine and mizolastine was 1h, and that of cetirizine was 2h. The half-life is about 24h, and the effect is long-lasting.

Including chronic idiopathic urticaria, perennial allergic rhinitis and other allergic diseases. In addition, it can relieve the symptoms of cold urticaria.

1. Treatment of allergic rhinitis (AR)

2. Treatment of chronic idiopathic urticaria (CIU)

Desloratadine Powder Raw Materials can be made into drugs with the following properties:

Desloratadine is a film-coated tablet, which appears white or off-white after removing the film coat.

(1) Desloratadine Tablets: Light blue film-coated tablets, white after removal of the coating.

(2) Desloratadine capsules: the contents are white or off-white granules.

(3) Desloratadine dispersible tablets: white or off-white tablets.

(4) Desloratadine syrup: orange-yellow clear viscous liquid.

(5) Desloratadine dry suspension: off-white to light pink powder granules or powder, sweet in taste.

The specifications are as follows:

(1) Desloratadine tablet: 5mg.

(2) Desloratadine capsule: 5mg.

(3) Desloratadine dispersible tablets: 5mg.

(4) Desloratadine syrup: 100ml: 50mg (50%).

(5) Desloratadine dry suspension: calculated as desloratadine, 0.5g: 2.5mg; 1g: 5mg.