Bepotastine Besilate CAS 190786-44-8 Pharma Powder Raw Materials

CAS:  190786-44-8

MF:  C27H31ClN2O6S

EINECS:  1806241-263-5

Specification​: 99% min Bepotastine Besilate

Sample: Bepotastine Besilate Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Bepotastine Besilate Powder Usage and Synthesis.

Bepotastine Besilate is a potent and long-acting histamine H1 receptor antagonist with platelet-activating factor (PAF) antagonist-like effects; experiments with human peripheral blood mononuclear cells suggest that the Antiallergic effects of this compound may be mediated by interleukin-5; bepotastine rapidly and effectively suppresses the three major symptoms of allergic rhinitis: sneezing, runny nose, and nasal congestion.

Bepotastine Besilate Powder is an anti-hypertensive drug and a selective beta1 receptor blocker. It is a white crystalline powder that can be administered by mouth or by injection.The mechanism of action of Bepotastine Besilate CAS 190786-44-8 is to reduce blood pressure by blocking beta1 receptors to reduce heart contractility and heart rate. It also reduces oxygen consumption by the heart, improves cardiac function, and may reduce the risk of cardiovascular disease. The antifungal drug, Bepotastine Besilate Raw Materials, is a potent and long-acting histamine H1 receptor antagonist that.

Betotastine was introduced in Japan for the treatment of allergic rhinitis. This structurally-related derivative of chlorpheniramine and ebastine is prepared by condensation of optically-resolved 4-[1-(4-chlorophenyl)-1-(2-pyridyl)-methoxy]piperidine with ethyl 4-bromobutyrate followed by ester hydrolysis. Betotastine is the seventh marketed non-sedating histamine H1 antagonist. Its very low sedative side effect is due to very poor penetration in the central nervous system. Besides its potent and long-acting activity in models of allergic rhinitis, betotastine was also shown to act as a PAF antagonist and inhibit LTD4 in tracheal smooth muscle and ileum, IL-5 production by human peripheral blood mononuclear cells as well as eosinophil infiltration in the airway and peripheral blood. As a consequence, it is currently being developed against other allergic and respiratory disorders.

Bepotastine Besilate (TAU 284) is a non-sedating, selective histamine 1 (H1) receptor antagonist with a pIC50 of 5.7.

Application/Function of Bepotastine Besilate Powder.

The primary indication for bepotastine besilate is hypertension, but it can also be used for the treatment of angina pectoris, post-myocardial infarction myocardial fibrosis, and heart failure. In addition, it can be used to treat conditions such as hyperthyroidism, cardiac arrhythmias, and migraine headaches. It is a potent and long-acting histamine H1 receptor antagonist with platelet-activating factor (PAF) antagonist-like effects; experiments with human peripheral blood mononuclear cells suggest that the anti-allergic effect of this compound may be related to the mediation of interleukin-5; Bepotastine rapidly and effectively suppresses the three main symptoms of allergic rhinitis: sneezing, runny nose and nasal congestion.

• 1. Bepotastine is a histamine H1 receptor anatagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).
• 2. Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7
• 3. An antifungal agent, benzbetostine is a potent and long-acting histamine H1 receptor antagonist with platelet-activating factor (PAF) antagonist-like effects; experiments with human peripheral blood mononuclear cells suggest that the anti-allergic effect of this compound may be related to interleukin-5 mediation; benzbetostine rapidly and effectively suppresses the three main symptoms of allergic rhinitis: sneezing, runny nose and nasal congestion.

Mechanism of action of Bepotastine Besilate Powder:

Bepotastine Besilate (BB) is a second-generation H1 antihistamine that, as an eye drop, is FDA-approved for the treatment of allergic conjunctivitis in the United States. In other countries, oral BB is widely available, primarily for allergic rhinitis (AR) and for the improvement of symptoms of urticaria and chronic pruritus, and has similar results to other drug treatments.

Side effects of betahistine benzoate are relatively rare, but still require attention. Common side effects include dizziness, weakness, hypotension, bradycardia, and gastrointestinal discomfort. When using betostatin besylate, heart rate and blood pressure need to be checked regularly, and you should follow your doctor's advice and dosing instructions.

Contraindications for betostatin besylate include severe heart block, myocardial infarction, asthma, and severe liver dysfunction. It should also not be used concomitantly with some medications, such as calcium channel blockers, insulin, and oral hypoglycemic agents.

Overall, betahistine benzoate is a safe and effective anti-hypertensive drug with fewer side effects and a wide range of indications. Contraindications and drug interactions should be noted when using it, and medical advice and dosing instructions should be followed.

Preparation process of Bepotastine Besilate Powder.

Packing And Shipping

• 1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
• 2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.