Clemastine Fumarate Powder CAS 14976-57-9 Raw Material

CAS:  14976-57-9

MF: C25H30ClNO5

MW: 459.96

EINECS: 239-055-2

Specification​: 99% min Clemastine Fumarate

Sample:  Clemastine Fumarate Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Clemastine Fumarate Powder Usage and Synthesis.

Clemastine Fumarate Powder is a potent, long-acting, fast-acting, highly selective histamine H1 receptor antagonist that simultaneously blocks H1 Clemastine Fumarate CAS 14976-57-9 is an anisole histamine H1 receptor antagonist. It can also be used to treat runny nose and sneezing caused by common cold.

Clomastine fumarate is a potent, long-acting, fast-acting, highly selective histamine H1 receptor antagonist that simultaneously blocks H1 receptors and antagonizes cytotoxicity, and is mainly used clinically for allergic dermatoses, allergic rhinitis and other allergic diseases, bringing a boon to patients who suffer from allergic diseases all year round. "Sting" drugs belong to a strong, long-acting, highly selective histamine H1 receptor blockers, and the central nervous system cholinergic receptors do not inhibit the effect of sedation and drowsiness, mostly used for allergic rhinitis, anti-allergic asthma, urticaria, eczema, dermatitis and pruritus. In recent years, "Sting" drugs have been increasingly emphasized for topical administration, and have been developed for nasal and ophthalmic topical use, thus becoming a class of non-hormonal drugs for the treatment of allergic rhinitis.

Application/Function of Clemastine Fumarate Powder.

Clemastine fumarate is the name of a western medicine. It is commonly used in the form of tablets, capsules, dry suspensions, oral solutions and injections. It is an antihistamine. It is mainly used for the treatment of allergic rhinitis, urticaria, eczema and pruritus and other allergic diseases. It can also be used for the anti-allergic treatment of bronchial asthma. Mainly used for the treatment of allergic diseases such as allergic rhinitis, urticaria, eczema and pruritus. It can also be used for the anti-allergic treatment of bronchial asthma.

Allergic rhinitis; allergic diseases such as urticaria, eczema and pruritus; also used in the anti-allergic treatment of bronchial asthma. It can also be used to treat runny nose and sneezing caused by common cold.

The main effect of Clomastine Fumarate Tablets is anti-allergic, which can be used to treat body rashes, hives, eczema, and also has a good auxiliary treatment effect for seasonal or year-round allergic rhinitis, and has a certain relief effect on bronchial asthma. The main ingredient of Clomastine Fumarate Tablets is Clomastine Fumarate Tablets, which are small white tablets. Patients may experience mild symptoms such as panic, chest tightness, loss of appetite, fatigue, early menstruation, vomiting, etc., which will not affect the efficacy of the medication and can continue to use it.

Although it can be used to treat allergic rhinitis, urticaria and other allergic skin diseases, it is not a hormone. This drug is usually taken orally and is used clinically as a prescription drug, so it should be used according to the doctor's instruction before use. The doctor should first determine whether it is suitable, and if it is suitable, it will be combined with a certain dosage and applied for a period of time to have a better effect of relieving allergy symptoms.

Clemastine fumarate tablets may cause some adverse reactions, including drowsiness, dizziness, loss of appetite, and other digestive system reactions, as well as hypotension, palpitations, tachycardia, thrombocytopenia in the blood system, and early menstruation in women.

Pharmacological Effects of Clemastine Fumarate Powder

Clemastine is a histamine H1 receptor antagonist of the diphenyl ether class. It selectively acts on H1 receptors, prevents histamine from acting on target cells, reduces capillary permeability, and has a mild effect against 5-hydroxytryptamine (5-HT) or choline. Clomastine has a strong antipruritic effect, with a rapid onset of action that lasts up to 12 hours. Clomastine is rapidly and almost completely absorbed by the body, reaching peak blood levels in 2-4 hours, with the strongest antihistamine effect in 5-7 hours. The effect lasts for 10-12 hours, sometimes up to 24 hours. The plasma protein binding rate is up to 95%. The elimination is biphasic, with half-lives of 3.6±0.9 h and 37±16 h. The active substance is mainly metabolized in the liver, and the metabolites (45-65%) are mainly excreted via the kidney, with only 0.1% excreted in the original form.

Clomastine fumarate is a strong antihistamine, which can block various pathological effects of histamine and has anticholinergic and sedative side effects. For example, it inhibits increased capillary permeability and dilation, edema formation, erythema and pruritus, and smooth muscle contraction in the gastrointestinal tract and respiratory system. In the vascular plexus, histamine-induced vasoconstriction and diastole can be blocked simultaneously. Depending on the dose, it may produce stimulation or inhibition of the central nervous system. There are also central or (and) peripheral anticholinergic effects. Pharmacological studies have shown that the drug acts by competitive blockade of H1 receptors and does not antagonize or inactivate histamine, nor does it affect the release of histamine.