Antineoplastic Irinotecan CAS 97682-44-5 Raw Materials Powder

CAS: 97682-44-5

MF: C33H38N4O6

Specification​: 99% min Irinotecan Powder

Sample: Irinotecan Powder

Brand: Henrikang

Appearance: Ligh Yellow Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

MADE IN CHINA Store:https://henrikang.en.made-in-china.com/

Irinotecan Powder Usage and Synthesis :

Large-scale clinical studies have shown that irinotecan hydrochloride has obvious inhibitory effect on a variety of tumors such as colon cancer, small cell lung cancer, rectal cancer, leukemia, etc., and it is still effective for fluorouracil resistant cases. Therefore, irinotecan hydrochloride has attracted wide attention all over the world. Antitumor drugs. It is a DNA synthesis inhibitor. It is a semi-synthetic derivative of camptothecin.

Irinotecan Powder is an oral drug used to treat lymphoma and chronic lymphocytic leukemia. It is a tyrosine kinase  inhibitor that stops the growth and spread of cancer cells.Irinotecan Raw Materials is approved by the FDA for the  treatment of various types of lymphomas and chronic lymphocytic leukemia. Irinotecan CAS 97682-44-5 is usually used as a  single agent or in combination with other drugs.

Application/Function of Irinotecan Powder .

Irinotecan is a semi-synthetic derivative of camptothecin, an inhibitor of topoisomerase I and an S-phase cell cycle specific antitumor agent. It has anti-tumor effects by interfering with the helix and non-helix of DNA in the replication phase, causing inhibition of nucleic acid synthesis, causing DNA single-strand breaks, preventing DNA replication and inhibiting RNA synthesis.

● Irinotecan is used in metastatic colon (rectal) cancer where conventional therapy is not effective.

●In combination with fluorouracil and calcium folinate for the treatment of advanced colorectal cancer patients who have not received prior chemotherapy; as a single agent for the treatment of advanced colorectal cancer patients who have failed fluorouracil-containing chemotherapy regimens.

●It is also effective in lung, breast, stomach, pancreatic, cervical, and ovarian cancers.

Production method of Irinotecan Powder .

Irinotecan hydrochloride is a light yellow powder with a melting point of 222~223℃. Very light yellow needle-like crystals or crystalline powder obtained from water, melting point 256.5°C. [α]D20+67.7° (C=1, water). UV maximum absorption (ethanol): 221, 254, 359, 372nm (ε53800, 36600, 26200, 25300). ph value of 2% aqueous solution is 4. Acute toxicity LD50 mice (rng/kg): 177.5 intraperitoneal, 765.3 oral.

Common side effects of Irinotecan .

These include delayed onset diarrhea, especially after 24 hours of dosing, and some acute cholinergic syndrome, early onset diarrhea, which occurs within 24 hours of dosing, followed by some hematologic neutropenia, nausea, vomiting, anorexia, abdominal pain, malaise, etc. This is a common adverse effect of many chemotherapy drugs.

The incidence of delayed diarrhea as an adverse effect of irinotecan is very high, and we will grade the symptoms of patients with delayed diarrhea.

Grade 3 to 4, the symptoms are more serious, such as an increase in the number of stools to more than seven times a day, fecal incontinence, etc.; Grade 4, a life-threatening diarrhea, also has a certain percentage.

Therefore, we will actively treat and prevent delayed diarrhea as an adverse reaction to Elitecan.

The main adverse effects of this drug are dose-limiting, toxic, and non-sequential, so we will basically get a good cure after good prevention and treatment.

The commonly used drugs for the treatment of delayed diarrhea include loperamide, octreotide, and simethicone.

Loperamide, also known as emmenagogue, is a very common drug used to treat irinotecan delayed diarrhea, which can inhibit gastrointestinal motility and increase the absorption of water and electrolytes.

However, it is worth noting that this drug cannot be used prophylactically before chemotherapy, but only after the emergence of diarrhea, and we have a saying that no prophylactic use of Emmenthal, no diarrhea no drug, and during chemotherapy we should stop all these drugs, avoid the intake of some accelerated intestinal peristalsis, coarse fiber food, drinks and other foods or drugs to accelerate or increase our The breakdown of diarrhea.