Antineoplastic Cyclophosphamide CAS 50-18-0 Raw Materials Powder

CAS: 50-18-0

MF: C7H15Cl2N2O2P

Specification​: 99% min Cyclophosphamide Powder

Sample: Cyclophosphamide Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

MADE IN CHINA Store:https://henrikang.en.made-in-china.com/

Cyclophosphamide Powder Usage and Synthesis .

Cyclophosphamide is one of the most commonly used alkylating antitumor agents. It is a white crystalline or crystalline powder at room temperature (liquefies when it loses its water of crystallization) and is stable at room temperature. It is soluble in water, but not very soluble. Aqueous solution is unstable, so it should be used within a short time after dissolution. Easily soluble in ethanol.

First synthesized by Arnold and Bourseaux in 1958, the synthesis of this compound and its derivatives was developed based on the structure and action of previous anticancer drugs. It is mainly used for tumor immunity. After entering the human body, it is catalyzed by liver microsomal enzymes to divide into alkylated phosphoramidite (or phosphoramidite nitrogen mustard), which has cytotoxic effect on tumor cells and has obvious inhibitory effect on many kinds of tumors.

Application/Function of Cyclophosphamide Powder.

It is suitable for the treatment of malignant lymphoma, multiple myeloma, lymphocytic leukemia, cervical cancer, prostate cancer, colon cancer, bronchial cancer, solid tumors such as neuroblastoma, ovarian cancer, breast cancer, various sarcomas and lung cancer. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome, and autoimmune diseases.

Cyclophosphamide Powder (Cyclophosphamide, abbreviated as CTX) is a chemotherapeutic drug that belongs to the alkylating agent class. Cyclophosphamide Raw Materials is commonly used to treat malignant tumors, autoimmune diseases and other diseases. Its mechanism of action is to inhibit DNA synthesis and cell division by binding to DNA, thus blocking the proliferation and spread of tumor cells. Also, Cyclophosphamide CAS 50-18-0 affects the immune system and decreases immune function, thus reducing the symptoms of autoimmune diseases.

Production method of Cyclophosphamide Powder .

Cyclophosphamide (abbreviated as CTX) is a non-specific cytotoxic drug of the cell cycle, but its effect on the G2 phase (late DNA synthesis) is more intense, and the main immunosuppressive mechanisms are:

1.  Decrease the absolute number of T and B lymphocytes, more pronounced in early phase on B lymphocytes.
2. Significantly inhibit the transformation of lymphocytes into mother cells after specific antigen stimulation. The inhibition after mitogen stimulation was not as strong as for specific antigens.
3. Inhibits antibody responses to neoantigens and delayed skin metaplasia.
4. Reduces elevated immunoglobulin levels, with the possibility of hypogammaglobulinemia after long-term use (several years).
5. In vitro selective inhibition of B-lymphocyte function, reduction of spontaneous immunoglobulin production by some B-lymphocytes, and inhibition of immunoglobulin production following stimulation of mitogens in general. Cyclophosphamide is not cytotoxic before metabolism, and its activation must depend on the oxidation of cytochrome P450 in the microsomal enzyme system of hepatocytes to form 4-hydroxycyclophosphamide, which then turns into the highly active phosphoramidite nitrogen mustard after ring opening, thus exerting cytotoxic effects.