Antineoplastic Cisplatin CAS 15663-27-1 Raw Materials Powder

CAS: 15663-27-1

MF: Cl2H6N2Pt

Specification​: 99% min Cisplatin Powder

Sample: Cisplatin Powder

Brand: Henrikang

Appearance: Yellow Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

MADE IN CHINA Store:https://henrikang.en.made-in-china.com/

Cisplatin Powder Usage and Synthesis .

Cisplatin is one of the most commonly used drugs in combination chemotherapy. It is an inorganic metal complex that dissociates chlorine and cross-links with DNA of cancer cells, thereby disrupting DNA function. It may form intra-strand or inter-strand cross-links with DNA, and may also form cross-links with DNA and protein, and inhibit cell mitosis, which is a non-specific drug of cell cycle.
 

Cisplatin Powder is a chemical drug that belongs to the platinum class of antitumor drugs. Cisplatin Raw Materials is commonly used to treat ovarian cancer, lung cancer, esophageal cancer, head and neck cancer and many other malignant tumors. Cisplatin CAS 15663-27-1 inhibits cancer cell DNA replication and repair by interfering with cancer cell growth and division. Cisplatin is usually administered intravenously. Side effects include nausea, vomiting, hair loss, anemia, and immunosuppression.

Application/Function of Cisplatin Powder.

Cisplatin has the advantages of broad anti-cancer spectrum, effective in depleted oxygen cells and strong action, and has been commonly used in the treatment of testicular, ovarian, uterine, bladder, neck, prostate and brain cancers with remarkable efficacy. However, cisplatin used for the treatment of cancer has certain toxicity and can cause side effects, so there is a need to continuously search for analogues with less toxicity and similar clinical effects to cisplatin.

Cisplatin (DDP) is one of the most commonly used drugs in current combination chemotherapy because of its broad anti-cancer spectrum, strong effect, synergistic effect with various anti-tumor drugs and no cross-resistance.

1. Reproductive system tumors: it has significant effect on ovarian cancer and testicular cancer, and the combination of DDP and ADM can achieve better effect on more than 40% of ovarian cancer; the efficiency and cure rate of DDP with BLM and VLB can reach 80% and 60% respectively for non-seminomatous cell testicular cancer. It can also be used for other reproductive system tumors such as choriocarcinoma and cervical cancer.
2. Head and neck cancer: nasopharyngeal carcinoma, thyroid cancer, laryngeal cancer, etc.
3. It is also effective for bladder cancer, lung cancer, malignant lymphoma, breast cancer, renal cell carcinoma, prostate cancer, soft tissue sarcoma and malignant melanoma.
4.  Others: malignant thoracic ascites; with radiotherapy, it has radiosensitizing effect.

To date, scientists from various countries have synthesized and tested thousands of metal complexes related to cisplatin and developed second-generation anti-cancer platinum complexes represented by carbon platinum. Third-generation anticancer metal complexes have also been discovered, represented by titanocene dichloride. These compounds are chemically unrelated to cisplatin, but they are more effective against certain cancerous lesions where cisplatin treatment is less effective and do not harm kidney function.

A great deal of research continues in this field, focusing on exploring the mechanisms of anticancer activity of metal complexes at the molecular level. Commercial cisplatin has been produced and research in this area has been conducted in China.

Due to the low concentration of intracellular chloride ion (4mmol/L), the chloride ion is replaced by water and has a positive charge, which has the effect of a bifunctional group similar to alkylating agent, and can bind to the bases of DNA in the nucleus, forming three forms of cross-linking, causing DNA damage, disrupting DNA replication and transcription, and also inhibiting RNA and protein synthesis at high concentrations.

Production method of Cyclophosphamide Powder .

Cisplatin, also known as cis-chloroplatinum, chloroplatinum, DDP, tin platinum, etoplatinum, cis-bis-chloroplatinum, is a metal platinum complex commonly used today, and the platinum atom in the molecule is important for its antitumor effect. However, only the cis-form is significant and the trans-form is not effective. It can be cross-linked to DNA strands and shows cytotoxic effects. After solubilization it can pass through the charged cell membrane in vivo without carrier transport.

The anticancer activity of cisplatin was not discovered until 1965 by Rosenberg and colleagues at the University of Michigan, USA. In their study of the effect of electric fields on the growth of E. coli, they found that placing a metallic platinum electrode in a culture solution containing ammonium chloride and passing a 2-amp current for two hours inhibited the growth of E. coli. Further studies showed that this was due to the role of cisplatin, a product of the chemical reaction between the electrolytic oxidation of trace amounts of platinum on the electrode to produce platinum ions and the ammonium chloride solution.

Rosenberg concluded that since cisplatin prevents cell division, it should have anti-cancer activity. Through anti-cancer tests, cisplatin proved to have good anti-cancer effect, which aroused people's interest in metal complex pharmacology and organized international cooperative research in chemistry, biology and medicine, finally making cisplatin successfully applied in the treatment of cancer.

Cisplatin (CDDP) can be said to be a veritable "old" drug, synthesized by M. Peyrone as early as 1845, so it is also known as Peyrone salt. 1971 cisplatin entered clinical trials, and in 1977 the patent of cisplatin was transferred to Schweppes, and in 1978 it was approved by the U.S. Food and Drug Administration (FDA). It is still one of the platinum-based anticancer drugs widely used in clinical practice. It has a cure rate of almost 100% for testicular cancer, and is also very effective for ovarian cancer, lung cancer, head and neck cancer, bone cancer and other malignant tumors. Therefore, it is also known as "the penicillin of anti-cancer drugs".

Drug Interactions.

• (1) Combined with aminoglycoside antibacterial drugs, amphotericin B or cephalothin, there is a nephrotoxic superimposed effect.
• (2) Methotrexate and bleomycin are mainly excreted by the kidney. The renal damage caused by this product will delay the excretion of the above two drugs, resulting in increased nephrotoxicity.
• (3) Combined with probenecid, it may cause hyperuricemia.
• (4) Combination with chloramphenicol, furosemide or etanercept can increase the ototoxicity of this product.
• (5) Antihistamine can mask the symptoms of tinnitus and vertigo caused by this product.