Daidzein CAS 486-66-8 Powder Raw Materials

CAS: 486-66-8

MF: C15H10O4

MW: 254.24

EINECS: 207-635-4

Specification​: 99% min Daidzein 

Sample: Daidzein Powder

Brand: Henrikang

Appearance: RED Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Daidzein Powder Usage and Synthesis.

Daidzein Powder (daidzein, 4',7-dihydroxyisoflavone, hereafter referred to as D) is one of the main active ingredients of Pueraria Mirifica and Soybean, Daidzein CAS 486-66-8 has obvious anti-arrhythmic, anti-hypoxic-ischemic, antispasmodic, estrogenic, promotes the formation of osteocytes and inhibits the growth of cancer cells. 

Daidzein has been shown to have antiarrhythmic, antihypoxic, antispasmodic, estrogenic, osteoclastogenic and cancer inhibitory effects. 

Daidzein Raw Materials are used in tablets or capsules for the treatment of coronary heart disease, cerebral thrombosis, cerebral infarction and sequelae of cerebral haemorrhage.

Daidzein Powder are part of the flavonoid class of isoflavones and are classified as a type of phytoestrogen, a non-steroidal compound with estrogen-like properties extracted from plants.

Daidzein Powder have been found to have weak estrogenic and weak anti-estrogenic effects. Soy glucosides are a solid substance insoluble in water.

Daidzein Raw Materials has a vasodilating effect, increases coronary flow, lowers blood pressure, slows heart rhythm and reduces myocardial oxygen consumption and anti-arrhythmic effects, and has significant antibacterial effects on Staphylococcus aureus and Escherichia coli.

It also has a significant antibacterial effect on Staphylococcus aureus and Escherichia coli. It can increase body weight and immune organ weight in mice.

Estrogen-like effects, treatment of menopausal syndrome, anti-osteoporosis, anti-estrogenic activity, prevention of breast cancer, endometritis, anti-hypoxic effect.  It can significantly prolong the survival time of mice under normobaric hypoxic conditions. 

Uses and functions of Daidzein Powder.

Daidzein Powder (3.0,5.0mg-kg-1) had a significant preventive effect on chloroform-induced ventricular fibrillation in mice, and soy glucosinogen (0.8,1.0mg-kg-1) had a significant therapeutic effect on aconitine-induced arrhythmias in rats. Daidzein Powder (0.2,0.3mg-kg-1) was also effective against epinephrine-induced arrhythmias in rabbits. Daidzein Powder (0.03%,0.05%) significantly reduced the action potential amplitude of the isolated sciatic nerve in toads.

Daidzein Powder (0.8,1.0mg-kg-1) had a preventive effect on calcium chloride induced ventricular fibrillation in rats, and significantly reduced the mortality rate in rats. The above effects were dose-dependent.

Soy glucosinolates had significant anti-arrhythmic effects. Aconitine can promote the opening of fast sodium channels and accelerate the inward flow of Na+, resulting in polymorphic ectopic rhythms, which can be effectively counteracted by Daidzein Powder, suggesting that Daidzein Powder may have a significant inhibitory effect on the inward flow of Na+ in the myocardial cell membrane.

Daidzein Powder also have a procaine-like local anesthetic effect, penetrating the sciatic nerve with similar ability to procaine. The action potential amplitude of toad isolated sciatic nerve was mainly due to Na+ inward flow, which was reduced by Daidzein Powder, further suggesting that soy sapogenins have an inhibitory effect on Na+ inward flow. Therefore, the anti-arrhythmic effect of Daidzein Powder may be related to the inhibition of Na+ or Ca2+ inward flow and anti-β-adrenergic receptors. 

Pharmacological Effects of Daidzein Powder.

Daidzein belongs to the flavonoid isoflavone, and is classified as a phytoestrogens, which is a non-steroidal compound derived from plants that has estrogen-like properties. It was found that daidzein had weak estrogenic and weak anti-estrogenic effects. Daidzein is a solid substance that is insoluble in water.

Production method of Daidzein Powder.

After comparison, resorcinol and p-hydroxyphenylacetic acid were used as the raw material, and the anhydrous zinc chloride catalyzed condensation, dimethylformamide dimethyl acetal and carbon unit transfer agent were used to produce soy glycosides. The product yield was as high as 43.0% and the quality was in accordance with pharmacopoeial standards.