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Pharmaceutical Trimethoprim / TMP Raw Materials Powder CAS 738-70-5 API Factory Supply
Product Overview:
Trimethoprim / TMP is a lipophilic and weakly basic ethylaminopyrimidine bacteriostat, also known as sulfonamide synergist, methoxybenzylaminopyrimidine, antimicrobial synergist, methoxybenzylaminopyrimidine, methoxybenzylpyrimidine, trimethoprim, trimethoprim, a white or off-white crystalline powder at room temperature, odourless and bitter in taste, slightly soluble in chloroform, slightly soluble in ethanol or acetone, virtually insoluble in water, soluble in Slightly soluble in chloroform, slightly soluble in ethanol or acetone, almost insoluble in water, soluble in glacial acetic acid.
The antibacterial spectrum of Trimethoprim/TMP is similar to that of sulfonamides, but the antibacterial effect is stronger, it is effective against Escherichia coli, Proteus mirabilis, Pneumocystis pneumoniae, Staphylococcus saprophyticus, and many kinds of gram-positive and gram-negative bacteria, but it is ineffective against Pseudomonas aeruginosa infections, the lowest inhibitory concentration is often lower than 10mg/L, and it is easy to cause bacterial resistance when used singly, therefore it is not usually used alone, it is mainly used in the form of a combination with sulfonamide. It is mainly used in combination with sulfonamides to treat urinary tract infections, intestinal infections, respiratory infections, bacillary dysentery, enteritis, typhoid fever, meningitis, otitis media, otorhinitis, sepsis and soft tissue infections, etc. It is effective against typhoid fever and paratyphoid fever. The efficacy of typhoid fever and paratyphoid fever is not less than that of ampicillin, and it can also be used in combination with long-acting sulfonamides for the prevention and treatment of drug-resistant falciparum malaria.
White crystalline powder, odourless, bitter taste. Melting point 199-203℃. Difficult to dissolve in water, ether, benzene, slightly soluble in chloroform, methanol, soluble in acetic acid.
Pharmaceutical Trimethoprim / TMP Raw Materials Powder CAS 738-70-5 API Factory Supply Attributes
CAS:738-70-5
MF: C14H18N4O3
MW: 290.32
EINECS: 212-006-2
Specification: 99% min Trimethoprim / TMP Powder
Sample: Trimethoprim / TMP Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance: White Powder
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Pharmaceutical Trimethoprim / TMP Raw Materials Powder CAS 738-70-5 API Factory Supply Details
Trimethoprim / TMP Powder Usage and Synthesis.
The antibacterial principle of Trimethoprim / TMP is to interfere with bacterial folate metabolism. The main mechanism of action is to selectively inhibit the activity of bacterial dihydrofolate reductase, so that dihydrofolate can not be reduced to tetrahydrofolate, and the synthesis of folic acid is the main component of nucleic acid biosynthesis, so the product prevents the synthesis of bacterial nucleic acids and proteins, and methocarbamol (TMP) and the bacterial enzyme of dihydrofolate reductase binds to the enzyme of mammals than the binding of 50,000 ~ 60,000 times more closely. Combined with sulfonamides can make the bacterial folic acid synthesis and metabolism was doubly blocked, there is a synergistic effect, so that the antibacterial activity of sulfonamides enhanced, and can make the bacteriostatic effect into bactericidal effect, reduce drug-resistant strains. In addition, this product can also enhance the antibacterial effect of a variety of antibiotics (such as tetracycline, gentamicin, etc.).
Uses and functions of Trimethoprim / TMP Powder.
Trimethoprim / TMP as an antimicrobial booster, also for the treatment of bacterial infections and coccidiosis in poultry
Novel oral broad-spectrum antibacterial drug. The antibacterial spectrum is similar to that of sulphonamides but more potent, effective against a wide range of Gram-positive and negative bacteria. As bacteria will be easy to develop resistance to this product, so it is not suitable for use as a separate antibacterial drug. Combined with sulfonamides, methotrexate can enhance the antibacterial effect several times to dozens of times. It is mainly used as a potentiator of sulfonamides. It is generally used in the ratio of 1:5. It can also be used as veterinary medicine for the treatment of septicaemia caused by avian coliform hepatic bacteria, chicken dysentery, avian typhoid fever, cholera, respiratory system secondary bacterial infections and so on. It can also be used in the treatment of coccidiosis.
Usage: Antibacterial potentiator, used alone for respiratory tract infection, urinary tract infection, intestinal tract infection and other diseases.
Preferred as antimicrobial agent, inhibitor of dihydrofolate reductase with prokaryotic enzyme selectivity; specific dosage inhibitor, widely used in the study of dihydrofolate reductase; inhibits tetrahydrofolate synthesis through prokaryotic specific dihydrofolate reductase (DHFR).
Pharmacological Effects of Trimethoprim / TMP Powder.
Trimethoprim / TMP is a bacterial dihydrofolate reductase inhibitor, the principle of its antibacterial action is to interfere with bacterial folate metabolism. Inhibitory spectrum: Streptococcus spp. including Streptococcus pneumoniae, Escherichia coli, Salmonella spp., Proteus mirabilis, Pneumocystis pneumoniae, Dysentery bacillus, Typhoid bacillus, Pertussis bacillus, etc. are susceptible to Trimethoprim. In addition, methotrexate also has a certain effect on Plasmodium and some fungi, such as Nucella, histoplasmosis, yeast. It has good antibacterial activity against Vibrio cholerae and Chlamydia trachomatis in vitro.Trimethoprim / TMP has no antibacterial effect against Pseudomonas aeruginosa, meningococcus and alkali producing bacteria.。
Production method of Trimethoprim / TMP Powder.
Trimethoprim / TMP as a selective inhibitor, commonly used in the preparation of selective medium, such as Campylobacter selective medium, Legionella selective medium, Clostridium botulinum selective medium and so on.
Working concentration:Preparation of selective medium:2.5~20mg/LScreening Campylobacter 10 or 20mg/LLegionella 2.5mg/LClostridium botulinum 4mg/LMethoxybenzidine solution preparation method:1.Firstly,sterilise all the instruments used in high temperature,disinfect the surface of the instrument and the working table.2.Weigh 0.500g of methoxybenzidine powder on the analytical balance and add 10mLDMSO(or lactobacillus) to it. 10 mLDMSO (or lactic acid solution, acetic acid solution) to dissolve. 3. Filter and sterilise into a sterile container using a 0.2 micron filter membrane, then dispense into 1.5 mLEP tubes. Screw cap tubes are not recommended and are easily contaminated. -20 degrees Celsius for storage.
To avoid contamination and repeated freezing and thawing, it is recommended to dispense into small sizes, e.g. 500uL.
