Pharmaceutical Sulfamethazine sodium Raw Materials Powder CAS 1981-58-4 API Factory Supply

Pharmaceutical  Sulfamethazine sodium Raw Materials Powder CAS 1981-58-4 API Factory Supply

CAS:1981-58-4

MF: C12H15N4NaO2S

MW: 302.33

EINECS: 217-840-0

Specification​: 99% min  Sulfamethazine sodium Powder

Sample:  Sulfamethazine sodium Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Sulfamethazine sodium Powder Usage and Synthesis.

Sulfamethazine sodium Powder is used for the following infections caused by susceptible organisms when the patient is unable to take them orally, e.g., acute simple lower urinary tract infections, acute otitis media, and soft tissue skin infections.

Sulfamethazine (Sulfadimethyldiazine) is a sulfonamide anti-infective agent used in animal husbandry.

Sulfamethazine sodium Powder is a sulfonamide antimicrobial agent, similar to sulfadiazine in antibacterial spectrum, with antibacterial effect against non-enzymatic Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella and other Enterobacteriaceae, Neisseria gonorrhoeae, Neisseria meningitidis, and Haemophilus influenzae. However, the resistance of bacteria to this product has increased in recent years, especially Streptococcus spp. and Neisseria spp. and Enterobacteriaceae. Sulfonamides are broad-spectrum antibacterial agents, similar to p-aminobenzoic acid (PABA) in structure, which can competitively act with PABA on dihydrofolate synthase in bacteria, thus preventing PABA from synthesising the folic acid needed by bacteria as raw material, and reducing the amount of metabolically active tetrahydrofolate, which is necessary for the bacterial synthesis of purine, thymine nucleoside and deoxyribonucleic acid (DNA), thus inhibiting the growth and reproduction of bacteria. This inhibits bacterial growth and reproduction.

Uses and functions of  Sulfamethazine sodium Powder.

Sulfonamides for infections caused by meningitis, pneumococci, haemolytic streptococci and certain gram-negative bacilli. An antimicrobial sulfonamide that induces CYP3A4 expression, as well as acetylation via N-acetyltransferase.

1. respiratory infections: e.g. pneumonia, bronchitis, etc;

2. genito-urinary infections: e.g. cystitis, prostatitis, etc;

3. infections of the digestive system: e.g. enteritis, gastritis, etc;

4. soft tissue skin infections: e.g. cellulitis, boils, etc;

5. acute tonsillitis, otitis media, etc.

Pharmacological Effects of  Sulfamethazine sodium Powder.

The pharmacological mechanism of Sulfamethazine sodium Powder works by inhibiting dihydrofolate synthesis in bacteria. It prevents bacteria from synthesising essential dihydrofolate, which results in the inability of bacteria to grow and multiply. The drug is effective primarily against gram-positive and gram-negative bacteria.

Production method of  Sulfamethazine sodium Powder.

Sulfamethazine sodium Powder belongs to sulfonamides, which is structurally similar to p-aminobenzoic acid (PABA), and can act competitively with PABA on the enzyme of difolate synthase in the body of bacteria, thus preventing the process of synthesising folic acid required by bacteria as raw material of PABA, and decreasing the amount of metabolically active tetrahydrofolate, which is necessary for the synthesis of purines in bacteria, thymine nucleosides and deoxyribonucleic acid (DNA), which are required for bacterial synthesis of purine, thymine nucleosides and deoxyribonucleic acid (DNA), thus inhibiting bacterial growth and reproduction. The action of sulphonamides is antagonised by PABA and its derivatives (procaine, bupivacaine), as well as by the presence of pus and the breakdown products of the tissues, which provide essential substances for bacterial growth.