Metformin Hydrochloride Raw Materials Powder

CAS: 1115-70-4

MF: C4H12ClN5

MW: 165.62

EINECS:  214-230-6

Specification​: 99% min Metformin Hydrochloride

Sample: Metformin Hydrochloride Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Metformin Hcl / Metformin Hydrochloride Powder API, High Quality Metformin Hydrochloride Raw Materials Powder, Pharmaceutical Raw Material 99% Pure Powder.

Metformin Hydrochloride Raw Materials is a biguanide oral hypoglycemic drug, also known as metformin hydrochloride, Gwarkia, Medicom, the hypoglycemic effect is weaker than phenelzine, Metformin Hydrochloride Raw Powder main effect is to reduce the secretion of A-cell glucagon, to promote the conversion of glucose to glycogen, with no stimulation of the glucagon.

Metformin Hydrochloride Raw Powder is mainly used to reduce the secretion of glucagon from A-cells and promote the conversion of glucose into glycogen, and has the property of not stimulating the secretion of insulin from pancreatic β-cells.

Uses and functions of Metformin Hydrochloride Raw Powder.

Clinically, Metformin Hydrochloride Raw Materials is mainly used for the treatment of type II diabetes mellitus patients with unsatisfactory dietary control, especially obese and hyperinsulinemic patients, with this drug not only has the effect of hypoglycemia, but also may have the effect of reducing body weight and hyperinsulinemia.

It may be effective in patients with poor efficacy of certain sulfonylureas, such as with sulfonylureas, small intestinal glycosidase inhibitors, or thiazolidinediones glucose-lowering drugs, the effect is better than that of the respective single use.

Metformin Hydrochloride Raw Powder is used in insulin-treated patients to reduce insulin dosage.

This product is a hypoglycaemic agent. It can reduce fasting and postprandial hyperglycemia in patients with type II diabetes mellitus, and HbAlc can be decreased by 1% to 2%.The mechanism of hypoglycemia of this product may be:

• ①Increase the sensitivity of peripheral tissues to insulin and increase insulin-mediated glucose utilisation.
• ② Increase glucose utilisation in non-insulin-dependent tissues, such as brain, blood cells, renal medulla, intestines and skin.
• (3) Inhibits hepatic gluconeogenesis and decreases hepatic glucose output.
• ④ Inhibits glucose uptake by intestinal wall cells.

Pharmacological Effects of Metformin Hydrochloride Powder.

The mechanism of action of hypoglycemia is as follows:

• 1. Increase the sensitivity of peripheral tissues to insulin, increase insulin-mediated glucose utilisation.
• 2. Increase glucose utilisation in non-insulin dependent tissues, such as brain, blood cells, renal medulla, intestines, skin, etc.
• 3. Inhibits hepatic gluconeogenesis and reduces hepatic glucose output.
• 4. Inhibit glucose uptake by intestinal wall cells.
• 5. Inhibit cholesterol biosynthesis and storage, reduce blood triglyceride and total cholesterol level.

Production method of Metformin Hydrochloride Powder.

Metformin Hydrochloride Powder is produced by reacting dimethylamine with dicyandiamide.