Pharmaceutical Bulk Salicylamide Powder

CAS:65-45-2

MF: C7H7NO2

MW:137.14

EINECS:200-609-3

Specification: 99% min Salicylamide Powder

Sample: Salicylamide Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Salicylamide Powder Usage and Synthesis.

Salicylamide is a widely used fine chemical intermediate, which can be used to synthesise nitrospiracetam, o-ethoxyformamide and other organic chemicals, also commonly used in medical, spices, fuel and rubber additives and other fields, at the same time, salicylamide is a large number of use of antipyretic and analgesic drugs, can be used for the treatment of fever and headache, neuralgia, arthralgia and rheumatic arthralgia and so on.

Uses and functions of Salicylamide.

Salicylamide has some antipyretic and anti-inflammatory effects, but its efficacy is worse than aspirin. It does not decompose in the stomach and has little irritation to the stomach. It is suitable for fever, headache, neuralgia, arthralgia and active rheumatism.

Salicylamide is not only an important fine chemical intermediate, but also a widely accepted and heavily used antipyretic and analgesic substitutes for fever and headache, neuralgia, arthralgia and or active rheumatism, etc., and has excellent therapeutic effects.

Pharmacological Effects of Salicylamide Raw.

Salicylamide is well absorbed from the gastrointestinal tract, with about 40 country, absorbed 1 hour after taking the drug, and 80 per cent absorbed after 5 hours, but blood concentrations are not too high. It is mostly unchanged to salicylic acid in the body, but combined with glucuronic acid and excreted in the urine, its pharmacological mechanism of action is unknown. This product has few gastrointestinal obstacles, because it is not decomposed in the stomach, so it has little irritation to the mucous membrane.

Production method of Bulk TSalicylamide Powder.

A method for the preparation of salicylamide, in a 1000-litre stainless steel reactor, 150 kg of methyl salicylate, 420 kg of toluene were added, heated to 40-45 ℃, ammonia was continuously passed through the ammonia reaction, the reaction temperature was controlled at 40-45 ℃, and the reaction pressure was controlled at 0.25-0.35 MPa, and the passage of ammonia was stopped after the ammonia reaction for 5 hours, and then the toluene and the reaction was heated up and recovered. Then toluene and methanol, a by-product of the reaction, were heated and recovered, and the remaining material was cooled down to 20 ℃, and salicylamide was obtained after crystallisation and centrifugation, with a yield of 97.8%.