Terbinafine HCl Raw Materials Powder

CAS:78628-80-5

MF:C21H26ClN

MW:327.89

EINECS:616-640-4

Specification: 99% min Terbinafine HCl Powder

Sample: Terbinafine HCl Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Terbinafine HCl Powder Usage and Synthesis.

Terbinafine hydrochloride can also be dispersed in the skin and, as a result, can reach quite high concentrations in hair follicles, hair and multilayered fat skin.

Terbinafine Hydrochloride can enter the nail plate during the last weeks of treatment.

The metabolites of Terbinafine Hydrochloride after biotransformation have no antifungal activity and they are excreted secondarily in the urine.

Its elimination half-life is 17 hours, there is no accumulation in the body, and its steady-state blood concentration is not affected by age. However, the elimination rate of terbinafine hydrochloride in patients with hepatic and renal insufficiency can be reduced, resulting in lower blood concentrations.

Uses and functions of Terbinafine HCl.

Terbinafine hydrochloride is an acrylamide with broad-spectrum antifungal activity, which has significant efficacy in foot fungus, grey nails, ringworm, jock itch, tinea pedis, etc., caused by fungi, and can also be used in bronchial asthma, wheezing bronchitis and emphysema.

1. Skin, hair and nail infections caused by Trichophyton (Trichophyton albicans, Trichophyton mustelii, Trichophyton verrucosum, Trichophyton guilloche and Trichophyton violetum), Microsporum canis and Serratia floccosum.

2. Various ringworm diseases (tinea corporis, tinea cruris, tinea cruris and tinea capitis, etc.) and yeast infections of the skin caused by Candida (Candida albicans, etc.).

3. Ringworm of the nails (nail fungal infections) caused by moulds.

Terbinafine Hydrochloride is indicated for the treatment of skin candidiasis such as tinea cruris, tinea pedis, tinea cruris, tinea corporis and tinea pedis, and it is also the best medication for treating grey nails.

Pharmacological Effects of Terbinafine HCl.

Terbinafine Hydrochloride is a broad-spectrum antifungal drug, which can highly selectively inhibit the fungal ergospiralene epoxidase, block the fungal cell membrane formation process of ergospiralene epoxidation reaction and interfere with the early biosynthesis of the fungal sterols, thus exerting the inhibitory and fungicidal effects.

Production method of Bulk Terbinafine HCl Powder.

1.Synthesis of crude terbinafine hydrochloride: add 12.5 ml of purified water, potassium carbonate (4.06 g, 29.2 mmol) to 100 ml three-necked reaction flask, stir to dissolve and then add N-methyl naphthyl methylamine (5.01 g, 29.2 mmol), then add 1-chloro-6,6-dimethyl-2-hepten-4-yn (4.57 g, 29.2 mmol), and then add 1-chloro-6,6-dimethyl-2-hepten-4-yn (4.57 g, 29.2 mmol), and then add 1-chloro-1,6-dimethyl-2-hepten-4-yn (4.57 g, 29.2 mmol). Raise the temperature to 80 ℃ reaction, 4 hours, cooled to room temperature, add 25 ml of ethyl acetate extraction, separated from the ethyl acetate phase and cooled to 0-10 ℃, dropwise addition of aqueous 6N hydrochloric acid, adjust H to 1, stirring for 1-2h, filtration, filter cake at 70 ℃ in a vacuum drying 4h to get the Turbinaprofen Hydrochloride crude product (8.51g, yield: 89%);

2. Purification of terbinafine hydrochloride crude: to 250ml single-necked bottle add terbinafine hydrochloride crude (8.51g, 26.8mmol), 106ml of purified water, heating reflux to dissolve clear, natural cooling to room temperature, ice bath cooling to 0-10 ℃, stirring for 1h, filtration, filter cake at 70 ℃ vacuum drying for 3h terbinafine hydrochloride finished products (7.66g, purity: 99.988%, yield: 89%). 99.988%, yield 90%).