Iguratimod Powder Raw Material

Product Name: Iguratimod Powder Raw Material

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Specification​: 99% min Iguratimod Powder

Test Method: HPLC

CAS: 123663-49-0

MF: C17H14N2O6S

Sample: Iguratimod Powder

Keywords: Iguratimod Powder, Iguratimod Powder Raw Material, Iguratimod Powder Supplier

Iguratimod Powder Raw Material introduce:
Wholesale Iguratimod Powder Raw Material in the China Factory, Iguratimod 99% white powder CAS 123663-49-0 99.9% White powder Iguratimod Powder Supplier and Manufacturer, High Quality Iguratimod Powder Raw Material CAS:123663-49-0, MF4:C2OH
Antirheumatic drug iguratimod, chemical name is N-[3-(formamido)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]methanesulfonamide, appearance It is white or off-white crystalline powder, odorless, tasteless, insoluble in water, slightly soluble in acetonitrile, soluble in dichloromethane, tetrahydrofuran, chloroform and ethanol, etc. It is a new type of antirheumatic drug for disease relief, which can relieve joint damage and immune abnormalities in chronic arthritis and autoimmune diseases, and inhibit the production of inflammatory cytokines and immunoglobulins. It has a remarkable effect and safety in the treatment of rheumatoid arthritis. It has anti-inflammatory and analgesic effects on acute and chronic inflammation. Unlike traditional non-steroidal anti-inflammatory drugs, iguratimod basically has no performance Ulcer-like adverse reactions in the gastrointestinal tract. This product can activate osteoclasts, promote bone resorption, and lead to bone loss. Inhibiting these pro-inflammatory factors can play a dual role in controlling rheumatoid arthritis and causing bone loss.

The main mechanism of action of iguratimod is: reducing the production of prostaglandins in inflamed tissues by selectively inhibiting cyclooxygenase-2; inhibiting the release of bradykinin in inflamed tissues; inhibiting the proliferation of antigen-specific T cells; reducing the risk of rheumatoid arthritis The levels of pro-inflammatory factors produced by B cells in patients with inflammation; stimulate osteoblast differentiation and bone construction; inhibit the expression of co-stimulatory factors and cytokine production in synoviocytes. It can inhibit the production of immunoglobulin, inhibit the production of cytokines, inhibit bone resorption and promote bone formation. It can inhibit the increase of bradykinin in the inflammatory response induced by kaolin, and its analgesic effect may be related to the inhibition of bradykinin.