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Rifampicin Raw Materials Rifampicin Powder
Product Overview:
Rifampicin is a semi-synthetic broad-spectrum antimicrobial drug of the rifamycin class, Generic name:Rifampicin Tablets, English name:RIFAMPICINTABLETS.Anti-tuberculosis drug,this product is sugar-coated tablets.After removing the coating,it shows orange-red or dark red colour. It has antibacterial activity against many pathogenic microorganisms.Rifampicin is well absorbed orally,and the blood concentration reaches the peak 1.5-4 hours after taking the drug. This product is used in combination with other anti-tuberculosis drugs for the primary and secondary treatment of various tuberculosis diseases,including the treatment of tuberculous meningitis.
Rifampicin Raw Materials Rifampicin Powder Attributes
CAS:13292-46-1
MF:C43H58N4O12
MW:822.94
EINECS:236-312-0
Specification: 99% min Rifampicin Powder
Sample:Rifampicin Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance: faint red to very dark red
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Rifampicin Raw Materials Rifampicin Powder Details
Rifampicin Powder Usage and Synthesis.
Rifampicin (also translated as: Rifamycin, Mepilex Rifamycin, Mepilex Rifamycin, Wilfosine, Sendoren, Rifampicin, or Rimidine, INN: Rifampicin) is a broad-spectrum antibiotic drug belonging to the family of rifamycins, with strong antibacterial effects against Mycobacterium tuberculosis, and also effective against Gram-positive or negative bacteria, viruses, and others. It is a red or dark red crystalline powder, insoluble in water.
It is usually taken orally as capsules or tablets, and works synergistically with other anti-tuberculosis drugs and delays the production of drug-resistant strains.
Uses and functions of Rifampicin.
Broad-spectrum antibiotic. It has bacteriostatic or bactericidal effects on Mycobacterium tuberculosis, Gram-positive bacteria and some Gram-negative bacteria.
Mainly used for drug-resistant tuberculosis phytobacteria and drug-resistant Staphylococcus aureus infections, leprosy also has a certain degree of efficacy.
It is a broad-spectrum antibiotic, and can enter into the cell, is a full-effect bactericidal drug, strong bactericidal force is a broad-spectrum antibiotic, on the divergent bacilli and Gram-positive and negative bacteria have strong bactericidal effect used as pharmaceutical intermediates have a broad-spectrum antimicrobial effect, on the Gram-positive cocci, Mycobacterium tuberculosis has good antibacterial activity, the antimicrobial spectrum is the same as rifampicin
Rifampicin is a broad-spectrum antibiotic with strong bactericidal effect against divergent bacilli and Gram-positive and negative bacteria, with strong bactericidal power.
Pharmacological Effect of Rifampicin.
1. Rifampicin is a semi-synthetic broad-spectrum antimicrobial drug of the rifamycin class, with antibacterial activity against a variety of pathogenic microorganisms.
It has obvious bactericidal effect on Mycobacterium tuberculosis and some non-tuberculosis mycobacteria (including Mycobacterium leprae) both inside and outside the host cell.
Rifampicin has good antibacterial effect on aerobic gram-positive bacteria, including enzyme-producing strains of staphylococci and methicillin-resistant strains, Streptococcus pneumoniae, other Streptococcus spp., Enterococcus spp., Listeria monocytogenes, Bacillus anthracis, Podococcus aerogenes, Bacillus diphtheriae, and anaerobic coccus.
It also has high antibacterial activity against aerobic gram-negative bacteria such as Neisseria meningitidis, Haemophilus influenzae and Neisseria gonorrhoeae.
Rifampicin also has good effect on Legionella spp. and has inhibitory effect on Chlamydia trachomatis, lymphogranuloma venereum and psittacosis.
Bacteria are cross-resistant to rifamycin antibiotics. Rifampicin binds firmly to the β-subunit of DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and preventing the enzyme from connecting with DNA, thus blocking the RNA transcription process and halting DNA and protein synthesis.
Product Method of Bulk Rifampicin Powder.
Rifampicin is a semi-synthetic derivative of rifamycin SV. Rifamycin SV is oxidised to rifamycin S, then formylated with formaldehyde and tert-butylamine to form 3-formyl tert-butylamine rifamycin S. Rifampicin is then obtained by reduction with vitamin C and condensation with 1-methyl-4-aminopiperazine.