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Phlorizin Raw Materials Phlorizin Powder
Product Overview:
Root bark glycoside is the glucoside of root bark, the chemical name is 1-(2-(beta-D-glucopyranosyloxy)-46-dihydroxyphenyl)-3-(4-hydroxyphenyl)-propanone, which belongs to dihydrochalcone substances in flavonoids.
Phlorizin Raw Materials Phlorizin Powder Attributes
CAS:60-81-1
MF:C21H24O10
MW:436.41
EINECS:200-487-1
Specification: 99% min Phlorizin Powder
Sample:Phlorizin Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:Yellow
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Phlorizin Raw Materials Phlorizin Powder Details
Phlorizin Usage and Synthesis.
Root bark glycoside is the glucoside of root bark, the chemical name is 1-(2-(beta-D-glucopyranosyloxy)-46-dihydroxyphenyl)-3-(4-hydroxyphenyl)-propanone, which belongs to dihydrochalcone substances in flavonoids.
Root bark glycosides are mainly found in the root bark, stems, young leaves and apple fruits of the apple tree, and also in small amounts in plants of the Asteraceae, Rhododendron, Leguminosae, Crustacea, and Liliaceae families. It has a variety of important biological activities such as lowering blood sugar, improving memory, anti-allergy, anti-cancer, etc. It has potential utilisation value in food, beauty and health care industries.
Uses of Phlorizin.
1. Food
Root bark glycosides have been approved as food additives.
Root bark glycosides can promote the absorption and utilisation of genistein (genistein, inhibiting the growth and metastasis of tumour cells), and the development of functional foods enriched with root bark glycosides and genistein has a broad market prospect in cancer prevention and treatment.
It is a very sweet natural sweetener and can be used as a sugar substitute food for diabetics with a sweet tooth.
It is oxidised by polyphenol oxidase to produce a product that can be converted into a bright yellow dye, which is highly water-soluble and can be used in the food processing industry as a substitute for artificial dyes, avoiding the toxic effects brought about by synthetic colours.
It has potential application value both as a food additive and functional food development and utilisation.
2. Pharmaceuticals due to the easy hydrolysis of root bark glycosides in the body to generate rhizopusin, and root bark glycosides in the small intestine with low absorption, so root bark glycosides and other compounds are often designed to become polymers used in the research and development of drugs.
2.Medicine
Because root bark glycosides are easily hydrolysed in the human body to generate rhizopusin, and root bark glycosides have a low absorption rate in the small intestine, so root bark glycosides are often designed with other compounds to become polymers used in the research and development of drugs.
3.Cosmetics
The antioxidant activity and anti-aging function of root bark glycosides have been confirmed by modern scientific research. The hydrolysate of root bark glycosides, rhizodendrin, can competitively inhibit tyrosinase activity, interfering with the synthesis of melanin, and its whitening effect is better than many whitening products on the market.
However, it should be noted that rhizopusin increases the expression of tyrosinase genes by activating the cAMP signalling pathway, which can lead to melanin production.
Biological activity of Phlorizin.
1. Hypoglycaemic effect
Diabetes mellitus is a major disease threatening human health, and the typical symptom of diabetes mellitus is high blood sugar. Most of their mechanism of action is to promote insulin secretion or increase insulin sensitivity.
A large number of existing studies have shown that root bark glycosides have the effect of reducing fasting blood glucose, and the mechanism of root bark glycosides lowering blood glucose lies in the competitive inhibition of glucose transporter carriers (SGLTs and GLUTs) on the transport of glucose molecules.
2.Antioxidant effectRoot bark glycosides have a significant protective effect on Drosophila melanogaster against oxidative damage caused by high-fat diet, enhance SOD and CAT activities, and can significantly extend the life span of Drosophila melanogaster, with strong antioxidant effect.
2.Antioxidant effects
Root bark glycosides have a significant protective effect on Drosophila melanogaster against oxidative damage caused by high-fat diet, and enhance SOD and CAT activities, which can significantly prolong the lifespan of Drosophila melanogaster, with strong antioxidant effects.
3.Physiological correlation with plants
Root bark glycosides are closely related to plant growth and development as well as physiological phenomena such as resistance.
It can resist many kinds of pathogenic bacteria, such as apple black star disease, fire blight and so on. However, it can have an inhibitory effect on the growth of certain plants. Low concentration of root bark glycosides can promote the growth of seedlings of Pinyin sweet tea, but too high concentration will cause plant heavy crop disorder.
Root bark glycosides can promote the regeneration of papaya embryos, especially the growth of roots. Therefore, its dosage is a key consideration when it is used as a plant growth regulator.
4. Other activities
In addition to its biological activities such as hypoglycaemic and antioxidant, root bark glycosides are anti-inflammatory and anti-cancer.
Synthesis method of Bulk Phlorizin Powder.
The precursors for the synthesis of root bark glycosides are malonyl-monoacyl-coenzyme A (Malonyl-CoA) and p-coumaroyl-coenzyme A (p-coumaroyl-CoA).
Firstly, p-coumaroyl-CoA generates 4-hydroxydihydrocinnamoyl-CoA via the NADPH pathway; then, malonyl-CoA and 4-hydrocinnamoyl-CoA generate rhizopodophyllin by the action of chalcone synthetase; and lastly, rhizopodophyllin glucosylates to generate rhizopodoside.