Raw Materials Periwinkle Herb Extract Powder

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Specification: 99% min Periwinkle Herb Extract Powder

Sample:Periwinkle Herb Extract Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:Brown

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Periwinkle Herb Extract Powder Physiological effect.

1.Tumour with vincristine sulfate treatment of Hodgkin's disease 22 cases, lymphosarcoma 11 cases, malignant reticulocyte hyperplasia, mycosis fungoides, leukemia, green tumour, mediastinal tumour 1 case each, reticulocyte sarcoma 6 cases. As a result, there were 4 cases of complete disappearance, 15 cases of obvious effect, 12 cases of effective, 6 cases of ineffective, 3 cases of deterioration, 3 cases of unknown, and the total effective rate was 72.1%.

2.Acute lymphatic leukaemia vincristine sulphate 10mg (1 dose), 2 times a week, intravenous injection, the total amount of 50mg. 5 cases of acute lymphatic leukaemia, 1 case of subacute lymphatic leukaemia, 2 cases of acute and chronic granulocytic leukaemia, 2 cases of complete disappearance and 3 cases of apparent effect.

3. 12g of periwinkle, 9g of Siegesbeckia, 6g of cassia seed and 6g of chrysanthemum in water, have good effect on lowering blood pressure.

Uses and Function of Periwinkle Herb Extract.

Anti-cancer, lowering blood pressure. Used for hypertension, malignant lymphogranuloma, choriocarcinoma, acute lymphatic leukaemia, childhood lymphatic leukaemia.

First of all, it has excellent blood cooling and antihypertensive effects on the human body, as well as excellent calming and tranquillising effects, for the treatment of hypertension, fire scalded bad have excellent effects.

Secondly, periwinkle extract has obvious anti-tumour effect on many kinds of tumours, such as mouse leukaemia, sarcoma, Fleet ascites carcinoma, breast cancer and so on. In addition, periwinkle extract can also be used to treat malignant lymphoma, choriocarcinoma, and other rare cancers.

Periwinkle extract mainly contains alkaloidal components such as periwinkle, vincristine, and epoxyvincristine. These alkaloidal components can bind to the β subunit of microtubule protein and inhibit the polymerisation of microtubule protein, which in turn affects the formation of spindle, thus inhibiting the division and proliferation of tumour cells.

In addition, periwinkle extract can also exert anti-tumour effects through other mechanisms, such as regulating cell signaling and inducing apoptosis, etc.

Pharmacological effect of Periwinkle Herb Extract.

1.Anti-cancer effect

Both periwinkle alkaloids and periwinkle alkaloids have anticancer effects. The mechanism of anticancer effect is that both periwinkle alkaloids and periwinkle alkaloids can denature the protein of spindle filament microtubule in the cell, so that the formation of spindle humour filament is impaired, thus inhibiting the mitosis of the cell, so that the cell division stops in the middle stage; in addition, they can also inhibit the synthesis of DNA and inhibit the enzyme of RNA polymerase, so that the synthesis of RNA is impeded.

2.Antihypertensive effect of periwinkle alkaloids injected intravenously, on anaesthetised cats and rabbits have antihypertensive effect, blood pressure falls fast, different from the slow fall of rosmarinus officinalis alkaloids preparation, and in the lowering of blood pressure at the same time accompanied by deepening of respiration, the amplitude of the larger; cut off the vagus nerve or atropine does not affect the effect of its lowering of blood pressure.

2.Antihypertensive effect

Intravenous injection of periwinkle alkaloids, anaesthetized cats, rabbits have antihypertensive effect, blood pressure falls fast, and the slow fall of rosmarinus officinalis alkaloids preparation is different, and at the same time in the lowering of blood pressure accompanied by deepening of respiration, the amplitude of the larger; cut off the vagus nerve or atropine does not affect the effect of its lowering of blood pressure. Total alkaloids also have the effect of coronary vasodilatation (belonging to the antispasmodic ganglion blocker).

3. Hypoglycaemic effect of foreign folk with periwinkle leaves and whole plant treatment of diabetes. Isolated from the periwinkle periwinkle knife Linnin alkaloids, epoxy periwinkle alkaloids, Rockneylin alkaloids and tetrahydrococklebone Changshan alkaloids have varying degrees of hypoglycemic effect, the beginning of the slower, but more persistent.

Leaves of the aqueous extract of normal and tetraoxymethylpyrimidine-induced diabetes in rabbits and dogs can also reduce blood glucose.

4. Diuretic effect

The extract of Vindolinine has diuretic effect on saline loaded rats.

5.Other effects

Periwinkle alkaloids have no excitatory effect on isolated uterus and intestinal tubes, and inhibit the isolated heart in large doses. It can be used as hemostatic agent when uterine bleeding is introduced abroad, and its root can be used for abortion. All its alkaloid parts have different degrees of antibacterial effect.

Production process of  Bulk Periwinkle Herb Extract Powder.