Tetrahydropalmatine Raw Materials Tetrahydropalmatine powder

CAS:2934-97-6

MF:C21H25NO4

MW:355.43

EINECS:/

Specification​: 99% min Tetrahydropalmatine Powder

Sample:Tetrahydropalmatine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Tetrahydropalmatine Powder Usage and Synthesis.

It has analgesic, sedative, hypnotic and stabilising effects. The analgesic effect is not as strong as quetiapine, but stronger than general antipyretic and analgesic.

1, gastrointestinal, hepatic and biliary system of the disease of dull pain pain relief effect is good, the effect of severe pain such as trauma is poor. 

2. Used for labour and menstrual pain.

3. Hypnotic, sedative effect is good, 20-30 minutes after serving to fall asleep, lasting 5-6 hours, no after-effects, so it can be used for temporary insomnia.

Uses of Tetrahydropalmatine.

Tetrahydropalmatine has analgesic, sedative, hypnotic and stabilising effects, the analgesic effect is not as strong as that of quetiapine, but stronger than that of general antipyretic and analgesic drugs. dl - Tetrahydropalmatine is the main active substance of the traditional Chinese medicine Yanhuisuo, and it can cause hypotension and bradycardia in rats through the antagonism of the striatal dopamine D2 receptor.

It is used as an analgesic for gastrointestinal and hepatobiliary headaches caused by internal diseases, dysmenorrhoea and labour pain relief.

Preparation of Tetrahydropalmatine.

A, berberine hydrochloride was ring-opened in p-toluenesulfonic acid, xylene and HCl at 70°C to obtain berberine demethylene hydrochloride.

B. Demethylene berberine hydrochloride was methyl etherified in potassium carbonate, methanol, dimethyl sulfate at 40℃ to obtain palmatine hydrochloride.

C、Palmatine hydrochloride in methanol, sodium borohydride under the condition of racemisation to get tetrahydropalmatine.

Produt Method of Tetrahydropalmatine.