HRK Supply Retinoic acid raw Materials powder Retinoic acid

CAS:302-79-4

MF:C20H28O2

MW:300.44

EINECS:206-129-0

Specification​: 99% min Retinoic acid Powder

Sample:Retinoic acid Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Retinoic acid Powder Usage and Synthesis.

Retinoic acid is mainly used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, epidermal nevus verrucosa, subkeratous impetigo, leukoplakia, pilaris rubrum and facial pityriasis simplex. In addition, it also has a certain preventive effect on skin cancer.

Retinoic acid can increase epidermal nuclear division and epidermal cell replacement, resulting in loose adhesion of stratum corneum cells, and easy to fall off. Removes existing acne and inhibits the formation of new acne. The replacement of follicle epithelium prevents the clogging of the cuticle plug. Keratin synthesis is also inhibited, which can affect epithelial metabolism. It can promote epithelial cell proliferation and differentiation, keratolytic effect.

Uses of Retinoic acid.

Retinoid acid (ATRA) is A retinoid receptor (RAR) and Retinoid X receptor (RXR) ligand that binds to RAR and RXR as transduction factors to regulate the growth and differentiation of normal and tumor cells. Cytochrome P450 (CYPs) catalyzed the hydroxylation of ATRA. Retinoic acid guides embryonic stem cells to evolve into neurons.

Retinoic acid, also known as retinoic acid or retinoic acid, is an intermediate product of vitamin A metabolism in this strain. It mainly affects bone growth and epithelial cell metabolism, and has the function of promoting epithelial cell proliferation and keratolytic. It is suitable for acne vulgaris, lichen planus (including oral lichen planus), leukoplakia, hair rufous pityriasis and facial pityriasis simplex. It can also be used as an adjuvant therapy for psoriasis (psoriasis), and can also be used to treat multiple verruca vulgaris and various skin diseases such as ichthyosis and follicular keratosis.

Pharmacological action of Retinoic acid.

This product can induce epidermal hyperplasia, thicken granular layer and spinous cell layer, and promote the differentiation of granular layer cells into stratum corneum by affecting the hydrolysis of K1 and K10 keratinase, the process of filaginogen to filaginin and the formation of crosslinked envelope in the late stage of epidermal cell differentiation. This product can significantly inhibit the formation of experimental acne, by regulating the abnormal keratosis of hair follicle sebaceous gland epithelium to remove the keratosis plug, thus playing a role in preventing and eliminating acne lesions. In addition, retinoic acid can also affect the production of melanin in melanocytes, and its effect is multi-site, inhibiting the activity of tyrosine hydroxylase, dopa oxidase and dihydroxyindole oxidase, thereby reducing the formation of melanin and alleviating skin pigmentation. It had no effect on tyrosinase activity and melanin composition in normal melanocytes.

Product method of Bulk Retinoic acid Powder.