Phentolamine mesilate raw Materials powder Phentolamine mesilate

CAS:65-28-1

MF:C18H23N3O4S

MW:377.46

EINECS:200-604-6

Specification: 99% min Phentolamine mesilate powder

Sample:Phentolamine mesilate powder

Packaging:1kg/bag, 25kg/drum

Brand:Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Phentolamine mesilate powder Usage and Synthesis.

Phentolamine mesylate tablets are a potential competitive blocker of α-receptors, by blocking the αl receptor of the vascular smooth muscle and possibly the α2 receptor, resulting in decreased peripheral resistance, vasodilation, can relax the smooth muscle of the penis, allowing more blood to flow into the cavernous tissue, while inhibiting blood flow from the cavernous body, resulting in erection. The oral bioavailability of phentolamine is low, and its oral preparations are clinically used for the treatment of erectile dysfunction.

Phentolamine mesylate for injection is a commonly used α-adrenergic receptor blocker. it can antagonize the effects of adrenaline and norepinephrine in blood circulation, dilate blood vessels and reduce the resistance of peripheral blood vessels. It is widely used in the diagnosis of pheochromocytoma and the treatment of hypertension caused by it, left ventricular failure and prevent skin necrosis.

Uses of Phentolamine mesilate.

Phentolamine mesylate is an adrenergic receptor blocker, commonly used in the treatment of male erectile dysfunction, pheochromocytoma diagnosis and treatment, heart failure, peripheral vascular spasmodic diseases.

Oral use of this product 30 minutes before sex can be used to treat erectile dysfunction in adult men up to 1 time per day. The maximum effect occurs 30 minutes after medication and lasts for 3-6 hours.

It is important to use this medicine under the guidance of a doctor, as it can have antihypertensive effects, and it is important to monitor blood pressure closely during medication.

Phentolamine mesylate is an adrenergic receptor blocker, commonly used in the treatment of male erectile dysfunction, pheochromocytoma diagnosis and treatment, heart failure, peripheral vascular spasmodic diseases.

Pharmacological action of Phentolamine mesilate.

1. Phentolamine mesylate is a short-acting, non-selective A-receptor (a1, a2) blocker that can antagonize the effects of adrenaline and norepinephrine in the blood circulation, causing blood vessel dilation and reducing peripheral vascular resistance.

2. Antagonizing the effect of catecholamine, it is used in diagnosis and treatment of pheochromocytoma, but has little effect on the blood pressure of normal people or essential hypertension patients.

3. It can reduce peripheral vascular resistance, reduce cardiac afterload, decrease left ventricular end-diastolic pressure and pulmonary artery pressure, and increase cardiac stroke volume, which can be used to treat heart failure. Carcinogenic, mutagenic and reproductive toxicity.

4. Long-term studies have shown that phentolamine mesylate has no significant carcinogenic, mutagenic and reproductive toxicity. In tests on rats, mice and rabbits, no teratogenic or embryonic phentolamine mesylate was found.

Product Methods of Phentolamine mesilate.