HRK Supply Aminophylline raw Powder

CAS:317-34-0

MF:C9H16N6O2

MW:240.27

EINECS:206-264-5

Specification: 99% min Aminophylline Powder

Sample:Aminophylline Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Aminophylline powder Usage and Synthesis.

1. Treatment of pulmonary hypertension: aminophylline can directly change the Ca2+ concentration in pulmonary artery wall and reduce Ca2+ outflow, inhibit PDE, relax smooth muscle, reduce pulmonary vascular resistance and pulmonary artery pressure, reduce pulmonary vascular extravasation, and eliminate pulmonary edema.

2. Treatment of sleep apnea syndrome and asphyxia of premature infants: aminophylline promotes the release of catecholamines sympathetic neurotransmitters by stimulating the respiratory center, enhancing the contractile force of diaphragm and hypoxia response, which is effective for sleep apnea and is better in children than in adults. Asphyxia of premature infants can also excite the myocardium and prevent bradycardia.

3. Prevention and treatment of lethargy and respiratory depression after general anesthesia: aminophylline excitation center, reduce carbon dioxide-induced respiratory initiation threshold, increase the body's response to pain and neuromuscular conduction function and muscle tone, reverse respiratory depression.

4. Treatment of intractable cough: suitable for cough caused by cold or inhalation of irritating gas, but need to exclude lung and bronchial organic lesions.

5. Treatment of arrhythmia: During myocardial ischemia, the release of adenosine increases significantly, which can cause angina pectoris, bradycardia, atrioventricular block, etc. After intravenous infusion of adenosine triphosphate, different degrees of atrioventricular block caused by small doses of aminophylline can be eliminated. The development of sick sinus syndrome may also be related to changes in the number of adenosine receptors, increased sensitivity, or abnormally slow breakdown of adenosine.

6. Treatment of acute nephritis and hemorrhagic fever with renal syndrome: aminophylline can inhibit the formation of thrombus and anti-basement membrane antibodies, dilate renal vessels, increase renal blood flow and filtration rate, improve renal microcirculation, activate the urinary function of glomeruli, and contribute to the relief of renal failure.

7. Treatment of aplastic anemia: aminophylline can stimulate hematopoietic stem cells, expand bone marrow blood vessels, and facilitate granulocyte production.

8. Treatment of transplant rejection: Aminophylline is an immunomodulatory drug that selectively activates inhibitory T cells. Inhibit acute rejection in patients with hormone tolerance, decrease blood creatinine and increase urine volume.

Drug interaction of Aminophylline.

1. Verapamil can interfere with the metabolism of theophylline in the liver, and can increase the blood concentration and toxicity of this product when combined.

2. Cimetidine can reduce the liver clearance of this product, and increase serum concentration or toxicity when combined.

3. Some antibacterial drugs, such as macrolide erythromycin, roxithromycin, clarithromycin, fluoroquinolones enoxacin, ciprofloxacin, ofloxacin, levofloxacin, clindamycin, lincomycin, etc., can reduce theophylline clearance rate and increase its blood concentration, especially erythromycin and enoxacin. When theophylline is used with the above drugs, the dosage should be appropriately reduced.

4. Phenobarbital, phenytoin sodium and rifampicin can induce hepatic drug enzymes and accelerate hepatic clearance of theophylline; Theophylline also interferes with the absorption of phenytoin sodium, and the plasma concentrations of both decrease, so the dose should be adjusted when used together.

5. Combined with lithium salt, the renal excretion of lithium can be increased; Affect the action of lithium salt.

6. When combined with mexiline, the clearance rate of theophylline can be reduced and the concentration of theophylline in plasma can be increased. The dose should be adjusted.

7. Combined with caffeine or other xanthines, it can increase its effect and toxicity.

8. Magnesium sulfate can antagonize the arrhythmia caused by this product.

Pharmacological action of Bulk Aminophylline powder.

1. Relaxation of airway smooth muscle: aminophylline can relax airway smooth muscle and relieve bronchospasm.

2. Immunomodulatory and anti-inflammatory effects: aminophylline can inhibit mast cells from releasing inflammatory transmitters and relieve airway smooth muscle spasm; It can also inhibit eosinophilic infiltration of bronchus.

3. Enhance respiratory muscle contraction: Prevent diaphragm fatigue and respiratory failure by improving respiratory function.

4. Excited respiratory center: make breathing excited, enhance the depth of breathing, but the respiratory rate does not increase.

5. Strong heart: Acts on the heart, antagonizes adenosine, prevents excessive release of adenosine, expands coronary arteries and peripheral vessels, promotes myocardial contraction, and increases cardiac output.

6. Diuresis: increase renal blood flow and glomerular filtration rate, and inhibit the reabsorption of renal tubules.

Product Methods of Aminophylline.

This product is a double salt of theophylline and ethylenediamine. Put theophylline into the mixer, stir and cool, spray the mixture of newly distilled ethylenediamine and distilled water with compressed air, spray and continue stirring for 10 minutes to obtain aminophylline.