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Tenofovir disoproxil fumarate Raw Materials powder
Product Overview:
Tenofovir fumarate is a nucleotide antiviral. As a nucleotide reverse transcriptase inhibitor, Tenofovir fumarate is a ring-opening nucleotide phosphate prodrug that can be taken orally. After oral absorption, Tenofovir is rapidly transformed into Tenofovir. Due to its high bioavailability, proven efficacy and good tolerance, TDF is now the recommended first-line anti-HIV drug with the highest sales. The synthesis method of Tenofovir fumarate has been reported in patent literature, but there are some problems such as excessive impurities in some intermediates, low optical purity, difficult operation, low yield, unqualified fumaric acid content and not suitable for industrial production
Tenofovir disoproxil fumarate Raw Materials powder Attributes
CAS:202138-50-9
MF:C12H14NO5S.Na
MW:307.3
EINECS:1592732-453-0
Specification: 99% min Tenofovir disoproxil fumarate powder
Sample:Tenofovir disoproxil fumarate powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Tenofovir disoproxil fumarate Raw Materials powder Details
Tenofovir disoproxil fumarate powder Usage and Synthesis.
Tenofovir fumarate is indicated in adult patients with CHB with evidence of viral replication and persistent elevated serum aminotransferase (ALT or AST) or active liver disease. Includes adult patients with HBeAg-positive or HBeAg-negative compensatory CHB.
Uses and functions of Tenofovir disoproxil fumarate.
Nucleotide reverse transcriptase inhibitor is a prodrug of Tenofovir (PMPA, 2), which is mainly used in the clinical treatment of human immunodeficiency virus infection.
Pharmacological action of Tenofovir disoproxil fumarate.
Tenofovir diisopropioxy methyl fumarate, tenofovir diisopropioxy methyl ester, is an ester precursor of Tenofovir and an acyclic 5' -adenosine monophosphate analogue. It has broad-spectrum antiviral effect and can inhibit HIV-1, HIV-2 reverse transcriptase and HBV polymerase, thereby inhibiting viral replication. When taken orally, TDF is hydrolyzed to Tenofovir, which is phosphorylated by cell kinases to the pharmacologically active metabolite Tenofovir diphosphate, which competes with 5' -triphosphate deoxyadenosine and participates in the synthesis of viral DNA. Upon entering the viral DNA, DNA elongation is blocked due to the lack of 3'-OH, thus inhibiting viral replication.
Product method of Bulk Tenofovir disoproxil fumarate.
