Pharmaceutical 98% Dihydromyricetin CAS 27200-12-0

CAS:27200-12-0

MF: C15H12O8

MW:320.25

EINECS:200-001-8

Specification: 99% min Dihydromyricetin

Sample:Dihydromyricetin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Dihydromyricetin Usage and Synthesis.

Dihydromyricetin ( dihydromyricetin, DMY), is a wild woody vine (Garcinia cambogia) extract of the genus Vitis in the family Vitis vinifera, also known as dihydromyricetin, dihydromyricetin, serpentine graphene, etc.

Dihydromyricetin is the extract of Garcinia Cambogia, the main active ingredient of Garcinia Cambogia, such substances have scavenging free radicals, antioxidant, anti-thrombotic, anti-tumour, anti-inflammatory and other peculiar effects; and dihydromyricetin is a more special kind of flavonoids, which can be used in lifting alcohol intoxication, preventing alcoholic liver, fatty liver, inhibiting the deterioration of hepatocytes, lowering the incidence of hepatocellular carcinoma, and resisting high blood pressure, Inhibit platelet aggregation in vitro and thrombus formation in vivo, reduce blood fat and blood sugar level, improve SOD activity and protect liver, etc. with special effects.

Uses and functions of Dihydromyricetin.

Dihydromyricetin is the extract of Garcinia Cambogia, the main active ingredient in Garcinia Cambogia is flavonoids, which have the effects of scavenging free radicals, antioxidant, anti-thrombotic, anti-tumour, anti-inflammatory, etc. Dihydromyricetin is a more special kind of flavonoids, which, in addition to having the general properties of flavonoids, has the effects of relieving alcohol intoxication, preventing alcoholic and fatty livers, inhibiting the deterioration of hepatocytes, and lowering the incidence of hepatocellular carcinoma.

Pharmacological Effect of Dihydromyricetin.

Antibacterial effect: Pharmacological experiments show that dihydromyricetin has antibacterial effect on Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, Bacillus aeruginosa, brewer's yeast, yeast, Penicillium, Aspergillus niger, Aspergillus flavus, Trichoderma reuteri, and Rhizoctonia solani, especially on the Gram-positive, Gram-negative coccus or bacillus with obvious effect.

Regulatory effect on blood glucose and lipid: Gavage pharmacological experiments in mice showed that dihydromyricetin can significantly inhibit tetracycline, epinephrine, streptozotocin and other induced elevation of blood glucose in mice, and at the same time increase the level of serum insulin, the pancreatic tissue, lymphocyte infiltration was significantly reduced, inflammatory response was significantly reduced, and the number of pancreatic islets was significantly increased.

Dihydromyricetin had a lowering effect on serum triacylglycerol (TG) content in streptozotocin-induced hyperglycaemic rats, but had no significant effect on serum total cholesterol (TC) and high-density lipoprotein cholesterol (HDL2C) content.

Hepatoprotective effect: Dihydromyricetin has a significant protective effect on carbon tetrachloride toxicity injury of rat hepatocytes cultured in vitro, D2 galactosamine and lipopolysaccharide-induced liver injury in mice. Dihydromyricetin protects the liver, accelerates the rapid decomposition of ethanol metabolite acetaldehyde into non-toxic substances, and reduces its damage to liver cells.

In addition, dihydromyricetin can improve the increase of serum lactate dehydrogenase activity caused by hepatocellular injury, inhibit the formation of collagen fibres in hepatic M-cells, so as to play the role of hepatoprotection and hepatoprotection, greatly reduce the damage of ethanol on the liver, so that the normal state of the liver can be quickly restored.Microherb test proved that dihydromyricetin can protect the liver, accelerate the rapid decomposition of ethanol metabolite acetaldehyde into non-toxic substances, reduce the damage to the liver cells.

Microherb test proved that dihydromyricetin can protect the liver, accelerate the rapid decomposition of acetaldehyde, a metabolite of ethanol, into a non-toxic substance, and reduce damage to liver cells. Dihydromyricetin has a rapid onset of action and a long-lasting effect, it is a good product for liver protection and alcohol detoxification.

Antioxidant effect: Dihydromyricetin with a purity of 98% can significantly inhibit the generation of malondialdehyde (MDA) in the homogenate of rat myocardial, hepatic and cerebral tissues, and with the increase of dihydromyricetin concentration the inhibition of the generation of MDA increased, and the scavenging rate of Dihydromyricetin with a content of 99% on the scavenging rate of diphenylphenylphenyltri-nitrophenylhydrazine (DPPH) radicals in the experimental system.

Dihydromyricetin can significantly inhibit the generation of MDA in oils and fats, with dihydromyricetin purity (60% to 90%) increased antioxidant effect enhanced; on animal oils and vegetable oils have strong antioxidant effect.

Anti-tumour effect: In recent years, anti-tumour pharmacodynamic studies have found that one of its active ingredients, serpentine small molecule compounds, has a relatively strong anticancer effect. In vitro anti-tumour research found that the compound can inhibit the growth of tumour blood vessels, regulate and enhance the cellular immune function to achieve the purpose of improving the effect of tumour treatment and improving the patient's vital signs, in leukaemia and nasopharyngeal carcinoma and other tumour models have shown a significant inhibitory role in the trial study.

Pharmacological Effect of Bulk Dihydromyricetin.