Hydrochlorothiazide CAS 58-93-5 Powder Raw Materials

CAS: 58-93-5

MF: C7H8ClN3O4S2

Specification​: 99% min Hydrochlorothiazide

Sample:  Hydrochlorothiazide Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Hydrochlorothiazide Powder Usage and Synthesis:

Hydrochlorothiazide, also known as dihydrochlorothiazide and dihydrochlorothiazide, is a thiazide diuretic with an intermediate diuretic effect. It acts on the cortical part of the ascending segment of the medullary collaterals to inhibit the active reabsorption of Cl- and the passive absorption of Na+, resulting in diuresis. In addition, it has hypotensive and antidiuretic effects. It is suitable for all kinds of oedema, especially cardiogenic oedema. It is also used as an antihypertensive agent for the treatment of mild and medium-sized hypertension. It is also effective in urolithiasis and idiopathic hypercalcaemia. Commonly used thiazide diuretics include hydrochlorothiazide, chlorothiazide and indapamide. It mainly inhibits the reabsorption of Na+ and Cl- in the proximal part of the distal tubule, resulting in an increase in the excretion of sodium chloride by the kidneys and producing diuretic effects, and is an intermediate diuretic. It has hypotensive effects and can be used in combination with Li's Medicine Patch, Hypotensive Shen Patch or Luo Bu Ma to enhance the effect of lowering blood pressure. It also has an anti-diuretic effect and can be used in the treatment of urolithiasis.

Pharmacokinetics of Hydrochlorothiazide Powder:

Rapid but incomplete absorption by mouth, with increased absorption by eating, probably associated with prolonged retention in the small intestine. It is partly bound to plasma proteins and partly enters the red blood cells. It is mainly excreted in its original form in the urine.

(1) Sodium excretion and diuretic effect: The product mainly inhibits the reabsorption of Na+ and Cl- in the anterior segment of the distal tubule and the proximal tubule (lighter effect), resulting in an increase in urinary sodium, potassium, chloride, phosphorus and magnesium excretion, and a decrease in urinary calcium excretion.

(2) Antihypertensive effect: It has a mild but definite hypotensive effect on systolic and diastolic blood pressure in the standing and lying positions, and also increases the hypotensive effect of other antihypertensive drugs.

(3) Anti-diuretic effect: It can reduce urine output in nephrogenic uremia, sometimes up to 50%, the exact mechanism of action is unknown.

Clinical Application of Hydrochlorothiazide Powder:

Hydrochlorothiazide (abbreviated as HCTZ, HCT or HZT) is currently the most commonly used oral thiazide diuretic in clinical practice. It is commonly used to treat hypertension and oedema caused by fluid accumulation. Other uses include the treatment of urolithiasis and renal tubular acidosis, and it can also reduce hypercalciuria, thereby reducing the risk of kidney stones. In addition, this drug is often used as a first-line drug for the treatment of hypertension. Hydrochlorothiazide is an oral medication and is sometimes mixed with other blood pressure lowering drugs to make a combination of ingots to enhance its effectiveness.

(1) Oedematous diseases: These include congestive heart failure, ascites in cirrhosis, nephrotic syndrome, oedema in acute and chronic nephritis, early stage of chronic renal failure, sodium and water retention due to adrenocorticosteroid and oestrogen therapy.

(2) Hypertension: It can be used alone or in combination with other antihypertensive agents, mainly for the treatment of primary hypertension.

(3) Central or nephrogenic urolithiasis.

(4) Nephrolithiasis: mainly for the prevention of stone formation from calcium salts.

Oral absorption is rapid but incomplete; feeding increases absorption and may be related to the prolonged retention of the drug in the small intestine. The drug is partly bound to plasma proteins and partly enters the red blood cells. The onset of action is 2 hours after oral administration, with a peak time of 4 hours and a duration of action of 6-12 hours, prolonged in cases of impaired renal function. The decrease in blood concentration is rapid at the beginning of the elimination phase after absorption and slows down significantly later, probably due to the entry of the drug into the red blood cells in the latter phase. It is excreted mainly in the urine in its original form.In addition, our company also produces and supplies OLED material intermediate