Food additive raw material Vitamin K1 CAS 84-80-0

CAS:84-80-0

MF: C31H46O2

MW:450.7

EINECS:201-564-2

Specification: 99% min Vitamin K1

Sample:Vitamin K1 Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White to almost white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Vitamin K1 Usage and Synthesis.

Vitamin K is dissolved in the lipids of the mitochondrial membrane, playing the role of electron transfer, vitamin K can increase intestinal peristalsis and secretion function, the lack of vitamin K smooth muscle tone and contraction is weakened, it can also affect the metabolism of some hormones.

It can also affect the metabolism of some hormones, such as delaying the decomposition of glucocorticoids in the liver, while having a similar effect to hydrocortisone, long-term injection of vitamin K can increase the endocrine activity of the thyroid gland and so on.

Uses and functions of Vitamin K1.

1、Promote blood coagulation;

2、Promote the synthesis of prothrombin in liver; 

3, Increase intestinal peristalsis and secretion function. Packing & Shipping : Packing: 25KG/ctn.

Vitamin drugs, used in vitamin K1 deficiency, hypoprothrombinemia, prevention and treatment of natural haemorrhage in newborns, etc.

As food fortifier. Can be used in infant food, the use of 420 ~ 475μg/kg.

Clinical applications of Vitamin K1.

1, used for haemostasis vitamin K1 body storage is small, 3 ~ 4 weeks in the body can be completely consumed, so you need to get from the gastrointestinal tract food often, such as access to the absorption process produces obstacles to the hepatic synthesis of coagulation factors are inhibited, prolongation of prothrombinogen, resulting in coagulation disorders, and cause bleeding symptoms, mainly manifested as skin and mucous membrane bleeding, internal bleeding, bleeding after traumatic injury and surgery, bleeding of the newborn and other Deep tissue bleeding, etc.

2, antispasmodic and analgesic when the cause of the stimulation of smooth muscle spasm and cause intense pain,can be used with vitamin K1, the mechanism is: vitamin K1 has a selective can be directly relax smooth muscle, at the same time on the smooth muscle contraction caused by acetylcholine has a significant inhibitory effect. Its analgesic mechanism is related to the opioid receptor and endogenous opioid substance mediation.

3, the treatment of capillary bronchitis capillary bronchitis is mainly caused by respiratory syncytial virus infection,the main manifestation of sudden wheezing, there is obvious capillary bronchial obstruction phenomenon, is a common paediatric emergency. 

In recent years, it has been found that capillary bronchitis contains to a large extent the airway response mediated by immune cells, and a large number of inflammatory substances similar to those specific to asthma patients have been found in the tracheal secretions contained in the airway secretions of children with capillary bronchitis and in the blood, such as viral IgE histamine-like substances, arachidonic acid and so on.

Product Method of Bulk Vitamin K1.

In the presence of zinc from o-methyl naphthoquinone and acetic anhydride reduction, acetylation to produce acetylated menaquinone; then hydrolysed in ammonia, and then in boron trifluoride catalyzed condensation with phytol in the ether to obtain dihydrogenated vitamin K1; and finally hydrolyzed, oxidized, purified and refined to obtain the product.