Nutritional fortifier Raw material L-Glutamine Powder

CAS:56-85-9

MF:C5H10N2O3

MW:146.14

EINECS:200-292-1

Specification: 99% min L-Glutamine Powder

Sample:L-Glutamine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

L-Glutamine Powder Usage and Synthesis.

L-glutamine is widely available in nature, e.g. in the free state in pumpkin and sunflower seedlings, and its N-ethyl compound (theanine) in tea. Although glutamine can be extracted from natural products, fermentation and synthesis are used for mass production.

Uses and functions of L-Glutamine.

Nutritional supplements, flavouring and aroma enhancers. Used in medicine to treat peptic ulcer, alcohol poisoning and improve brain function.

L-Glutamine is converted into glycosamine in the body, as the precursor of synthesising mucin, it can promote the healing of ulcers, mainly used as peptic ulcer medicine. In addition, it is also used as a brain function improver and for the treatment of alcoholism.

Characteristic of L-Glutamine.

1. It participates in the biosynthesis of glucosamine, a constituent of mucin in the mucous membrane of the digestive tract, thus promoting the repair of mucous membrane epithelial tissues and contributing to the elimination of ulcer foci. At the same time, it can pass the blood-brain barrier to promote brain metabolism and improve brain function, and it is an important nutrient for brain metabolism like glutamic acid.

2. It exists in tobacco leaves and smoke.

3. It has value in the field of immunity. It is used in organisms to convert toxic ammonia into non-toxic glutamine,which is excreted through urine. It is generally not involved in the composition of proteins

Production Method of  Bulk L-Glutamine Powder.

L-glutamine is widely available in nature, e.g. in the free state in pumpkin and sunflower seedlings, and its N-ethyl compound (theanine) in tea.Although glutamine can be extracted from natural products, fermentation and synthesis are used for mass production.

1. The synthetic method is obtained from L-glutamic acid-5-methyl ester ([1499-55-4]) by condensation, addition,salt formation and hydrolysis. Glutamic acid is esterified with methanol in the presence of concentrated sulphuric acid, and the resulting esterified solution is added dropwise to a mixture of methanol and carbon disulphide, and ammonia is passed through under cooling while dropping. After the dropwise addition of the esterified solution, the ammonia was continued to be passed, then triethylamine was added, and the product was placed in a closed chamber at 30℃ for 40h.

After concentration under reduced pressure to drive off the ammonia, the γ-methyl-L-glutamic acid-N-ammonium diammonium salt concentrate was obtained. It was heated to 40-45°C and acetic acid was added. After stirring for 30 min, carbon disulfide was removed under reduced pressure, at which time a large number of crystals were precipitated. Then add an equal volume of methanol, placed at 0 ℃ for 12h, filtration, the crude glutamine. After activated carbon decolourisation, recrystallisation to get the finished product.

2. Fermentation method will be glucose or acetic acid, ethanol as a medium carbon source, with the yellow Pseudomonas aeruginosa (Brevibacteriumflavum) strain fermentation, glucose yield of 39g / L, yield of 39%.