Nutritional Supplements Vitamin K3 Powder

CAS:58-27-5

MF:C11H8O2

MW:172.18

EINECS:200-372-6    

Specification: 99% min Vitamin K3 Powder

Sample:Vitamin K3 Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Vitamin K3 Powder Usage and Synthesis.

Vitamin K3 is white or off-white crystalline powder, agglomerated after moisture absorption, easily soluble in water and hot ethanol, insoluble in ice ethanol, insoluble in benzene and, aqueous solution PH4.7-7. It is stable at room temperature, easily decomposed when exposed to light. Vitamin K3 is a pro-coagulant, it can be used to treat some bleeding disorders caused by vitamin K deficiency, vitamin K3 is also called naphthoquinone, it can promote the formation of plasminogen, but also has a diuretic effect, can reduce blood pressure, sometimes vitamin K3 is used as a colouring agent or food additives.

Uses and functions of Vitamin K3.

Stable in air, decomposes in sunlight.1G is soluble in about 60 ml of ethanol, 10 ml of benzene, 50 ml of vegetable oil, soluble in chloroform and carbon tetrachloride. Insoluble in water. The ethanol solution is neutral to litmus paper. The solution does not decompose when heated up to 120°C. It is not decomposed when exposed to alkali or reducing agents.

Destroyed by alkali and reducing agents. Toxic, LD50 (mouse, oral) about 500mG/kG. irritating. Commodity still have sodium bisulfite naphthoquinone, is a white crystalline powder.

Odourless or slightly special smell. It is hygroscopic. Easily decomposed and become yellow or purple when exposed to light. Soluble in water, slightly soluble in ethanol, almost insoluble in ether and benzene. Uses: Biochemical research

VK3 is a raw material for feed additives, which can mainly promote the synthesis of plasminogen in the liver of livestock and poultry, and promote the synthesis of plasma clotting factors in the liver, and is a haemostatic agent.

Functionality of Vitamin K3.

The specific functions and roles of vitamin K3 include the following aspects:

First, promote blood coagulation, vitamin K3 can make fibrinogen into fibrin.

Second, involved in energy metabolism, vitamin K3 is an important component of the composition of the cellular respiratory chain is an intermediate product of oxidative phosphorylation in vivo.

Third, increase muscle elasticity, vitamin K3 can promote intestinal peristalsis, stimulate the secretion of the digestive glands, so that the digestive tract function normally.

Vitamin K3 is also used in clinical practice, mainly for the treatment of hypertension, eruption, acute pharyngitis eye obstruction.

Product method of  Bulk Vitamin K3 Powder.

1. Methyl naphthalene is obtained by oxidation with chromic anhydride. Dissolve 2-methylnaphthalene in glacial acetic acid, stirring and cooling to below 40 ℃, slowly add chromic anhydride and an equal amount of water mixture, so that the temperature is maintained at 35-40 ℃.

After addition, hold at 40℃ for 0.5h, raise the temperature to 70℃ and hold for 45min, then raise the temperature to 85℃ and hold for 15min, pour the reactants into a large amount of water, and precipitate 2-methylnaphthalene quinone under constant stirring.

Filtering, the filter cake was washed with water repeatedly until the aqueous solution had no acidic flavour, and filtered dry to obtain 2-methylnaphthoquinone. Yield 51%. 2-methylnaphthalene can also be used in sodium dichromate, potassium dichromate oxidation yield is about the same.

2. 2-methyl naphthalene hydroquinone was obtained by cycling methylbenzoquinone and butadiene, and then oxidised by chromic acid. Methylbenzoquinone was added to glacial acetic acid to dissolve, and butadiene was passed to the desired amount at 20°C or less.

After closed and standing for 20h, heating to make the remaining butadiene escape, continue to heat to about 110 ℃ reflux 3h, and then distillation under reduced pressure to recover glacial acetic acid about 30%. Then cooled to below 40 ℃, slowly add chromic acid and an equal amount of water mixture, so that the temperature is maintained at 65-70 ℃, add the end, at 70-80 insulation 1h to produce menaquinone.