Nutritional Supplements Folic Acid Powder

CAS:59-30-3

MF:C19H19N7O6

MW:441.4

EINECS:200-419-0

Specification​: 99% min Folic Acid Powder

Sample:Folic Acid Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White to Off-White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Folic Acid Powder Usage and Synthesis.

Folic acid is a dark yellow substance, not easily soluble in water, its sodium salt is more soluble. It is heat-stable in neutral and alkaline solutions, but decomposes in acidic solutions at temperatures exceeding 100°C. It is also a good source of folic acid, and its sodium salt is damaged by light. Folic acid and its sodium salt are destroyed by light in solution.

Folic acid isolated from liver and yeast is mainly derivatives containing three glutamates or seven glutamates.

The vast majority of dietary folic acid is polyglutamate compounds that are not absorbed intact into the bloodstream. Experiments with pteroyl polyglutamates with 14C labelling of the second glutamyl residue were broken down to pteroylglutamate during absorption, and there was no radioactive folate in the serum, while 14C was present in the exhaled gas.

The breakdown of the polyglutamic acid chain takes place in the cells of the intestinal mucosa. There are small stores of folic acid in the liver. The 4-hydroxyl group in the pteridine nucleus is substituted for the amino group to become 4-amino folate, an antagonist of folate that hinders nucleic acid synthesis.

Uses of Folic Acid.

Folic acid can improve megaloblastic anaemia, pregnant women intake of safe amount of folic acid can prevent vascular sclerosis, to prevent foetal deformity, preterm delivery; In addition, pregnant women need to be in the first trimester of pregnancy on the start of folic acid supplementation in order to meet the needs of the gestation period, because the general folic acid intake of the human body 4 weeks after the transformation can play a physiological role.

Lactating women can promote milk secretion by supplementing folic acid.

Folic acid supplementation can improve tongue redness and pain, depression, fatigue, insomnia; prevent intestinal parasites and food poisoning; promote skin health, reproduction of oral mucosal ulcers; with pantothenic acid and p-aminobenzoic acid can prevent grey hair; when the body is weak to take can promote appetite.

Function of Folic Acid.

Folic acid has become an extremely important micronutrient due to the gradual recognition of its importance in the diet, especially the progressive research on folic acid and birth defects, cardiovascular disease and tumours. Since 1 January 1998, the United States has mandated the fortification of certain cereals with folic acid.

The DA provides for the fortification of 1.4mg of folic acid per 1kg of cereal food (bread, flour, breakfast cereals, rice, etc.) (DHHS, 1996).

Therefore, it is necessary to update the DRIs for folic acid while revising our RDA of 1988. The active form of folic acid is tetrahydrofolate (THFA), and the enzyme folate reductase requires NADPH to reduce folic acid to tetrahydrofolate by adding four hydrogen atoms to positions 5, 6, 7, and 8 of the chattering nucleus.

Tetrahydrofolic acid is a one-carbon group carrier, formyl, formaldehyde and methanol and other one-carbon group suppliers are formylglutamic acid, purine, serine, glycine and so on.

The one-carbon cluster participates in the N6 or N10 position of tetrahydrofolate. In this form, folic acid plays an important role in the synthesis of purines and pyrimidines, in the interconverting action of amino acids, and in certain reactions of methylation.

For example, the formyl group carried by tetrahydrofolate is used in the following various reactions:

1. Carbon at positions 2, 5 and 8 in purine synthesis;

2. Conversion of glycine to serine;

3. Methylation of homocysteine to form methionine;

4. Synthesis of thymine from uracil;

5. Synthesis of choline from ethanolamine;

6. Methylation of niacinamide to form N′-methylniacinamide and so on. Folic acid deficiency produces megaloblastic anaemia, choroiditis and diarrhoea.

Production Method of Folic Acid.

An orange-red folic acid precipitate was obtained by the cyclisation reaction of p-aminobenzoylglutamic acid, 2,4,5-triamino-6-hydroxypyrimidine and trichloroacetone in the presence of sodium metabisulphite and sodium acetate at a temperature of 36-40°C for 6h, maintaining a Ph value of 3.4~3.6.

The product can also be obtained by substituting α,β-dibromopropionaldehyde for trichloroacetone and condensing under similar conditions.