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Riboflavin 5'-Monophosphate Sodium Salt Raw Materials Powder
Product Overview:
Sodium Riboflavin Phosphate is a precursor drug for Flavin Mononucleotide (FMN) and Flavin Adenine Dinucleotide (FAD), Chinese alias Vitamin B2 Sodium Phosphate, Sodium Flavin Mononucleotide, Sodium Riboflavin-5'-(Dihydrogen Phosphate) Mono Sodium Salt, FMN and FAD are important cofactors of the flavinase family. Flavinases catalyze many biochemical reactions, most notably oxidative allosteric reactions, and they are key factors in cellular respiration.
Riboflavin 5'-Monophosphate Sodium Salt Raw Materials Powder Attributes
CAS:130-40-5
MF:C17H22N4NaO9P
MW:480.35
EINECS:204-988-6
Specification: 99% min Riboflavin 5'-Monophosphate Sodium Salt
Sample:Riboflavin 5'-Monophosphate Sodium Salt Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:Yellow
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Riboflavin 5'-Monophosphate Sodium Salt Raw Materials Powder Details
Riboflavin 5'-Monophosphate Sodium Salt Powder Usage and Synthesis.
Sodium Riboflavin Phosphate is a vitamin drug. Riboflavin (vitamin B2) is an important nutrient in the body and plays a key role in energy metabolism. This drug is a precursor drug for flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are important cofactors of the flavinase family.
Flavinases catalyze many biochemical reactions, most typically redox reactions, and they are key factors in cellular respiration.FAD and FMN deliver hydrogen in the mitochondrial transport chain, generating cellular energy in the process.
Uses of Riboflavin 5'-Monophosphate Sodium Salt.
The main uses of sodium riboflavin phosphate are:1, it can promote cell development and regeneration;2, it can also promote the continued growth of hair, nails, skin;3 it can help to prevent and eliminate the inflammatory reaction of the oral cavity, tongue and lips, which is also known as oral reproductive syndrome;4 it can also help to reduce the fatigue of the eyes, and enhance the vision;5 it can affect the effect of human body on the absorption of iron.
Physiological effect of Riboflavin 5'-Monophosphate Sodium Salt.
According to the literature, after oral administration, riboflavin is absorbed mainly in the proximal small intestine, food promotes the absorption of the product, and bile salts accelerate the absorption of the product.
In the dose range of 2 to 25 mg, its bioavailability is 50 to 60%, the maximum absorption of a single oral dose is 27 mg, and the excess is excreted in the feces. Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are less well absorbed. The drug enters the circulation via the portal vein into the liver before reaching the tissues.
Most serum riboflavin is transported by albumin or immunoglobulins and diffuses through a concentration gradient into the cell. Within the cell, riboflavin is converted to FMN by flavin kinase, and FMN is converted to FAD by FAD synthase, which is the major form of riboflavin present in tissues.
Riboflavin in excess of the body's requirements is excreted primarily from the kidneys, as are some of its metabolites. The half-life of this drug is 66 to 84 minutes for oral or intramuscular administration.
Synthesis method of Bulk Riboflavin 5'-Monophosphate Sodium Salt Powder.
The current synthesis method mainly involves phosphorylation of riboflavin with phosphorus trichloride in a mixed solvent of pyridine and acetonitrile, followed by hydrolysis of the reaction mixture and neutralization with sodium hydroxide to obtain sodium riboflavin phosphate.
There is also a synthetic method in which γ-butyrolactone is used for the reaction instead of pyridine. The products produced by the above synthesis methods have low content of sodium riboflavin phosphate, which is difficult to meet the requirements of the Chinese Pharmacopoeia, high content of riboflavin diphosphate and high content of free phosphoric acid; more impurities, low quality; and large amount of contaminated waste liquid disposal.
The main factors affecting the quality of sodium riboflavin phosphate are related substances and free phosphoric acid content, the relevant substances are riboflavin diphosphate and free riboflavin, of which riboflavin diphosphate is 3′,4′-riboflavin diphosphate, 3′,5′-riboflavin diphosphate, 4′,5′-riboflavin diphosphate and the sum of riboflavin diphosphate; Pharmacopoeia standard control limit of the content of the upper limit are 6%.