bulk gamma-cyclodextrin powder cas no supplement

CAS: 17465-86-0

MF: C48H80O40

MW: 1297.12

EINECS: 241-482-4

Specification: 99% min Gamma-cyclodextrin powder

Sample: Gamma-cyclodextrin powder Avaliable

Packaging: 1kg/bag, 25kg/drum

Brand:  Ausreson

MOQ: 1 kg

Appearance: white powder

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

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Gamma-cyclodextrin powder Classification.

γ-cyclodextrin has a larger cavity than β-cyclodextrin, so the cavity can contain a wider range of guest molecules; it has better water solubility. At room temperature 25°C, the solubility of γ-cyclodextrin is 25.6g/100ml, while the solubility of α-cyclodextrin is 12.7g/100ml water and the solubility of β-cyclodextrin is only 1.88g/100ml water. Its application prospects are broader than β-cyclodextrin, but due to its small production scale, its price is high, which limits the promotion of its application.Фармацевтический гамма-циклодекстрин - оптовый поставщик

Uses of Gamma-cyclodextrin.

China Gamma-Cyclodextrin suppliers Uses of cyclodextrin in the field of chemistry Cyclodextrin is a valuable chemical reagent.Pharmazeutisches Gamma-Cyclodextrin - Großhandelslieferant

When it is present, the fluorescence intensity of the fluorescent pigment will increase significantly, so Buy Gamma-Cyclodextrin can be used for the analysis of proteins and amino acids; it can also be used to separate long-chain organic compounds, racemates, etc. In addition, adsorbents made from cyclodextrin can be used as adsorption for chromatographic analysis. It can also be used as a complexing agent, and Pharmaceutical grade Gamma-Cyclodextrin can also be used in enzyme activity research and tissue culture agents. This product should be sealed and stored in a dry place.Proveedor mayorista de gamma-ciclodextrina grado farmacéutico

Novel Drug Delivery

Product Methods of Bulk Gamma-cyclodextrin powder.

The hydrolyzed starch is acted on by cyclic maltodextrin glucose transferase (CGTase, EC2.4.1.19), and then purified by one of the following methods: l-cyclodextrin is precipitated with a complex of a macrocyclic compound, then extracted with n-decane, and the solvent is stripped; crystals are obtained from the purified mother liquor containing l-cyclodextrin by ion exchange or gel filtration chromatography; obtained by ultrafiltration and reverse osmosis membrane separation.Fornecedor atacadista de gama-ciclodextrina grau farmacêutico

Are cyclodextrins safe for humans?

The FDA generally considers alpha-, beta- and gamma-cyclodextrins to be safe. They have been used for the delivery of a variety of drugs, including hydrocortisone, prostaglandins, nitroglycerin, itraconazole, and chloramphenicol. Cyclodextrins confer solubility and stability to these drugs.Fournisseur en gros de gamma-cyclodextrine qualité pharmaceutique

What is gamma-cyclodextrin used for?

Gamma-Cyclodextrin is a stabilizer, emulsifier, carrier and formulation aid. It is recognized as safe (GRAS) in the United States.

What are the benefits of cyclodextrins?

Studies have shown that cyclodextrins can improve the solubility of hydrophobic drugs, and recent studies have extended the use of cyclodextrins to controlled drug release and nanotechnology.

Q1: What distinguishes Gamma-Cyclodextrin from Alpha and Beta variants?

A: Gamma-Cyclodextrin contains eight glucose units (compared to six in α-CD and seven in β-CD), creating a larger internal cavity (9.5 Å vs. 6.0 Å for β-CD). This structural difference provides higher aqueous solubility, greater inclusion capacity for bulkier molecules, and improved safety profiles—particularly reduced nephrotoxicity compared to β-CD.

Q2: Is Gamma-Cyclodextrin safe for consumption?

A: Yes, extensive toxicological studies support γ-CD safety. The European Food Safety Authority (EFSA) established an acceptable daily intake (ADI) of "not specified" for food applications, indicating very low concern. In pharmaceutical contexts, γ-CD exhibits superior renal safety compared to β-CD at equivalent doses.

Q3: How does Gamma-Cyclodextrin improve drug bioavailability?

A: γ-CD forms non-covalent inclusion complexes with hydrophobic drug molecules, effectively "dissolving" them within its hydrophilic exterior. This molecular encapsulation increases aqueous solubility, enhances dissolution rates, and can protect drugs from degradation—collectively improving bioavailability by 2-10 times for poorly soluble compounds.

Q4: What types of compounds form stable complexes with Gamma-Cyclodextrin?

A: γ-CD effectively complexes molecules with molecular weights between 200-800 g/mol containing aromatic rings or aliphatic chains. Ideal candidates include steroids, fat-soluble vitamins, non-steroidal anti-inflammatory drugs, terpenes, flavonoids, and many agrochemical actives. The larger cavity particularly accommodates bulky molecules like vitamin D analogues.

Q5: How should Gamma-Cyclodextrin be stored for optimal stability?

A: Store γ-CD in sealed containers at ambient temperature (15-25°C) with relative humidity below 65%. Properly stored, pharmaceutical-grade γ-CD maintains stability for at least three years. Unlike some excipients, γ-CD does not require refrigeration or special atmospheric controls.

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