API Colchicine Raw Material Colchicine Powder supplier

Colchicine Raw Material Colchicine Powder

CAS: 64-86-8

MF: 399.44

MW: 384.26

EINECS: 200-598-5

Specification​: 99% min Colchicine powder

Sample: Colchicine powder Avaliable

Packaging: 1kg/bag. 25kg/bag

Brand: Ausreson

MOQ: 1 kg

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Colchicine Raw Material Powder Usage and Synthesis

China Colchicine Raw Material Factory Supply Colchicine Nutritional Supplement Colchicine Powder Raw Material, High Quality Colchicine Powder Purity 99% is also known as colchicine, is an alkaloid extracted from the bulbs and seeds of the plant Colchicine, family Liliaceae.

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Mechanism of Action

Colchicine exerts its anti-inflammatory and pharmacological effects through a unique mechanism of action, primarily focused on its influence on cytoskeleton function.

Its core action is to inhibit the polymerization of β-tubulin into microtubules, a process crucial for cytoskeleton integrity. By interfering with this process, colchicine effectively prevents the activation, degranulation, and migration of neutrophils, which are key players in the inflammatory response of gout.

Notably, colchicine does not inhibit the phagocytosis of uric acid crystals, but it appears to prevent phagocytes from releasing an inflammatory glycoprotein. This dual mechanism of action allows it to control the inflammatory response without affecting uric acid metabolism.

In addition to its anti-inflammatory effects, colchicine also exerts its antimitotic effect by disrupting the formation of the mitotic spindle. This property also explains its toxic effects in rapidly proliferating tissues such as skin, hair, and bone marrow.

Uses and functions of Colchicine Powder

Colchicine, also known as colchicine, is an alkaloid extracted from the bulbs and seeds of the plant Colchicine, family Liliaceae, naturally occurring in the lily plant Garland and the Lijiang Mountain Cichlid Mushroom, with a content of 0.11% and 0.1%, respectively. Pale yellow needle-like crystals.

Slightly smelly, bitter taste. Melting point 157℃, easily soluble in cold water, alcohol, chloroform and formaldehyde, poor solubility in hot water, not easily soluble in benzene and ether, almost insoluble in petroleum ether, 0.5% solution pH 5.9, hydrolysed by ammonia can make the toxicity reduced.

Manufactory Supply Colchicine Powder Raw Material, High Purity Colchicine Powder Nutritional Supplement Colchicine Raw Powder, High Quality Colchicine Raw Powder.

Colchicine has inhibition of cell mitosis, anti-tumour effects.

Colchicine is effective in acute gout, can rapidly relieve pain and can prevent arthritic attacks, its mechanism of action is related to the inhibition of leukocyte proliferation and activity, affecting the release of lysosomes.

The pharmacological effect of this product is to reduce the activity and phagocytosis of leukocytes in inflammatory tissues, reduce the inflammation caused by uric acid crystals, so as to exert anti-inflammatory, oedema and analgesic effects, so it has a selective anti-inflammatory effect on acute gouty arthritis.

In addition, it is also a mitotic toxin, with strong inhibition of cell division, so that the cell stops in the division phase, resulting in the death of tumour cells, so it can be used in cancer treatment.

Bioactive pharmacological effects of Colchicine Raw Powder

It is clinically used for the treatment of acute attacks of gouty arthritis, prevention of acute attacks of recurrent gouty arthritis, familial Mediterranean fever, leukaemia, skin cancer, Hodgkin's disease, aplastic anaemia and so on.

It is also used for cycle-specific treatment of breast cancer, lung cancer, esophageal cancer, cervical cancer, nasopharyngeal cancer, Hodgkin's disease, chronic granulocytic leukaemia, skin cancer and other malignant diseases in M stage.

Production method of Colchicine Powder

• This product is an alkaloid extracted from the bulb of Lilium shanzhi mushroom, family Liliaceae. The powder of shan ci mushrooms was extracted with 85% ethanol by heating and refluxing for 4h, and the ethanol solution obtained was concentrated to semi-gelatinous substance under reduced pressure, and diluted with distilled water.
• The filtrate after acidification with 10% sulfuric acid was extracted with chloroform, and then the chloroform extract was concentrated,
• The crude colchicine obtained by crystallisation was recrystallised, i.e. the finished product. The total yield of 0.15% for the raw medicine Shan Ci mushrooms powder count. Most of the foreign countries are extracted from the bulbs of the plant colchicine in the genus Colchicine of the lily family.

Proveedor de materia prima de colchicina (API) en polvo
Fornecedor de matéria-prima de colchicina (API) em pó
Lieferant von Colchicin-Rohstoff (API) als Pulver
Fournisseur de matière première de colchicine (API) en poudre
Поставщик сырья колхицина (API) в порошке