Bulk drug Raw Materials Lomefloxacin Hydrochloride Powder

CAS:98079-52-8

MF: C17H20ClF2N3O3

MW: 387.81

EINECS:627-337-1

Specification​: 99% min Lomefloxacin Hydrochloride Powder

Sample: Lomefloxacin Hydrochloride Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: white to off-white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Lomefloxacin Hydrochloride Usage and Synthesis.

Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone that is active against Gram-negative and Gram-positive bacteria.

Lomefloxacin inhibits bacterial DNA-promoting enzymes (topoisomerase II) and topoisomerase IV, which are required for bacterial DNA transcription and replication.

DNA-promoter enzymes are considered to be the primary quinolone targets in Gram-negative bacteria.Topoisomerase IV is considered the primary target of Gram-positive bacteria. Inhibition of topoisomerases leads to strand breaks, superhelixes and resealing of bacterial chromosomes.

As a result, DNA replication and transcription are inhibited. Lomefloxacin can be used to treat a wide range of infections including respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. 

Compared with other quinolone antibacterial drugs, lomefloxacin has the advantages of easy administration and no need for theophylline dose adjustment.

At present, Lomefloxacin Hydrochloride has been widely used in the treatment of respiratory diseases such as acute exacerbation of chronic bronchitis caused by sensitive strains of bacteria, bronchodilator infections, acute bronchitis, pneumonia and other respiratory disorders, as well as urological infections such as acute pyelonephritis,complicated urinary tract infection, acute exacerbation of chronic urinary tract infections, acute prostatitis,gonorrhoea simplex and other infections of the abdominal cavity, the biliary tract, the intestines and other infections.

It is also used for typhoid fever, bacterial infectious diseases of skin and soft tissues, such as folliculitis, impetigo,boils, traumatic infections and secondary infections of eczema, secondary infections of tinea pedis, paranasal sinusitis, otitis media, blepharitis and so on.

Uses and functions of Lomefloxacin Hydrochloride.

Lomefloxacin Hydrochloride Tablets, Lomefloxacin Hydrochloride Capsules, Lomefloxacin Hydrochloride Dispersible Tablets, Lomefloxacin Hydrochloride Granules: used for the following infections caused by sensitive bacteria:

1, respiratory tract infections: acute exacerbation of chronic bronchitis, bronchial dilatation with infection, acute bronchitis and pneumonia.

2、Genitourinary infections: acute cystitis, acute pyelonephritis, complicated urinary tract infection, acute attack of chronic urinary tract infection, acute and chronic prostatitis and Neisseria gonorrhoeae urethritis or cervicitis (including those caused by enzyme-producing strains) and so on.

3、Gastrointestinal bacterial infections: caused by Shigella, Salmonella, enterotoxin-producing Escherichia coli,hydrophilic Aeromonas, Vibrio parahaemolyticus and so on.

4、Abdominal cavity, biliary tract, typhoid fever and other infections.

5, Bone and joint infections.

6、Skin and soft tissue infections.

7, Systemic infections such as sepsis.

8, Other infections, such as paranasal sinusitis, otitis media, blepharitis.

Lomefloxacin Hydrochloride Cream: for the treatment of bacterial infectious skin diseases. Such as impetigo,follicles, tinea pedis secondary suppurative infection, eczema secondary infection, and other superficial confined infections.

Lomefloxacin Hydrochloride Ophthalmic Gel, Lomefloxacin Hydrochloride Eye Drops: Used for external eye infectious diseases caused by sensitive pathogenic bacteria, such as conjunctivitis, keratitis, corneal ulcers,dacryocystitis, postoperative infections and so on.

Lomefloxacin hydrochloride ear drops: for otitis media, otitis externa, tympanitis caused by sensitive bacteria.

Pharmacological Effects of Lomefloxacin Hydrochloride.

1, Lomefloxacin hydrochloride is a quinolone antibacterial drug. It has high antibacterial activity against Enterobacteriaceae such as Escherichia coli, Shigella, Klebsiella, Aspergillus and Enterobacter; Haemophilus influenzae and Neisseria gonorrhoeae are also highly sensitive to this product; it also has certain antibacterial effect against Actinobacillus, Pseudomonas and other Pseudomonas spp., Staphylococcus spp. and Pneumococcus and Haemolytic Streptococcus.

2、Lomefloxacin hydrochloride inhibits DNA synthesis and replication by acting on the A subunit of DNA helicase in bacterial cells.

Drug interactions of  Bulk Lomefloxacin Hydrochloride Powder.

1、This product has little effect on the intrahepatic metabolism of theophylline drugs and caffeine, and on the clearance process in the body.

2、Nutritional agents and vitamins containing metal ions should not be taken within 2 hours before and after taking this product.

3、Combination with fenbufen can cause central excitation and seizures.

4, probenecid can delay the excretion of the product, so that the average area under the curve (AUC) increased by 63%, the average time to peak (Tmax) extended by 50%, the average peak concentration (Cmax) increased by 4%;therefore, the combination of this product can be toxic due to the increase in blood concentration.

5, can enhance the role of oral anticoagulants such as warfarin, etc., should monitor the prothrombin time and other items.

6、Urinary alkalinising agents can reduce the solubility of the product in the urine, leading to crystalluria and nephrotoxicity.

7, dehydroxyinosine (DDI) preparations containing aluminium and magnesium can be chelated with quinolones,should not be combined.

8、Combination with cyclosporine, cyclosporine blood concentration can be increased, must monitor cyclosporine blood concentration, and adjust the dose.

9, aluminium thiosulphate and acid-forming drugs can slow down the absorption rate of the product by 25%, the area under the curve (AUC) decreased by about 30%, such as in the product before taking 4 hours or after taking 6 hours of aluminium thiosulphate and acid-forming drugs will have little effect.