Pharmaceutical raw material Rifampicin CAS 13292-46-1

CAS:13292-46-1

MF: C43H58N4O12

MW:822.94

EINECS:236-312-0

Specification: 99% min Rifampicin

Sample:Rifampicin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:faint red to very dark red

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Rifampicin Usage and Synthesis.

Rifampicin is a semi-synthetic broad-spectrum antimicrobial drug of the rifamycin class, Generic name: Rifampicin Tablets, English name: RIFAMPICINTABLETS.Anti-tuberculosis drug, this product is sugar-coated tablets. After removing the coating, it shows orange-red or dark red colour. It has antibacterial activity against many pathogenic microorganisms.

Rifampicin is well absorbed orally, and the blood concentration reaches the peak 1.5-4 hours after taking the drug. This product is used in combination with other anti-tuberculosis drugs for the primary and secondary treatment of various tuberculosis diseases, including the treatment of tuberculous meningitis.

Uses and functions of Rifampicin.

Broad-spectrum antibiotic. It has bacteriostatic or bactericidal effects on Mycobacterium tuberculosis, Gram-positive bacteria and some Gram-negative bacteria. Mainly used for drug-resistant tuberculosis phytobacteria and drug-resistant Staphylococcus aureus infections, leprosy also has a certain degree of efficacy.

It is a broad-spectrum antibiotic, and can enter into the cell, is a full-effect bactericidal drug, strong bactericidal force is a broad-spectrum antibiotic, on the divergent bacilli and Gram-positive and negative bacteria have strong bactericidal effect used as pharmaceutical intermediates have a broad-spectrum antimicrobial effect, on the Gram-positive cocci, Mycobacterium tuberculosis has good antibacterial activity, the antimicrobial spectrum is the same as rifampicin

Rifampicin is a broad-spectrum antibiotic with strong bactericidal effect against divergent bacilli and Gram-positive and negative bacteria, with strong bactericidal power.

Pharmacological Effect of Rifampicin.

Antimicrobial activity. The drug has significant bactericidal effect on Mycobacterium tuberculosis and some non-tuberculous mycobacteria (including Mycobacterium leprae, etc.) both inside and outside the host cell.

Rifampicin has good antibacterial effect on aerobic gram-positive bacteria, including enzyme-producing strains of staphylococci and methicillin-resistant strains of staphylococci, Streptococcus pneumoniae, other Streptococcus spp., Enterococcus spp., Listeria monocytogenes, Bacillus anthracis, Podococcus aeruginosa, Bacillus diphtheriae, and anaerobic coccus.

It also has high antibacterial activity against aerobic gram-negative bacteria such as Neisseria meningitidis, Haemophilus influenzae and Neisseria gonorrhoeae. Rifampicin also works well against Legionella spp. and inhibits Chlamydia trachomatis, lymphogranuloma venereum and psittacosis.

Bacteria are cross-resistant to rifamycin antibiotics. Rifampicin binds firmly to the β-subunit of the DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and preventing the enzyme from attaching to DNA, thus blocking the RNA transcription process and halting DNA and protein synthesis.

Product Method of Bulk Rifampicin.

Rifampicin is a semi-synthetic derivative of rifamycin SV. Rifamycin SV is oxidised to rifamycin S, then formylated with formaldehyde and tert-butylamine to form 3-formyl tert-butylamine rifamycin S. Rifampicin is then obtained by reduction with vitamin C and condensation with 1-methyl-4-aminopiperazine.