Pharmaceutical raw materials Penicillin G Potassium Powder

CAS:61-33-6

MF:C16H18N2O4S

MW:334.39

EINECS:200-506-3

Specification: 99% min Levofloxacin Hcl Powder

Sample:Penicillin G Potassium Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Crystals

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Penicillin G Potassium Powder Usage and Synthesis.

Penicillin is an organic acid that is stable and insoluble in water. It can be combined with metal ions or organic bases to form salts, commonly used in clinical practice are sodium salt and potassium salt.

Penicillin potassium or sodium salt is white crystalline powder, odourless or slightly specific odour, with moisture attraction.

Uses and functions of Penicillin G Potassium.

It is mainly used for various infections caused by gram-positive bacteria, such as septicaemia, pneumonia, nephritis, mastitis, endometritis, traumatic infections, swine dengue, swine lymph node swelling, rabbit and avian staphylococcosis, streptococcus, anthrax, malignant oedema, emphysematous gangrene, equine glanders and so on.

Penicillin is also used to treat actinomycosis and leptospirosis.

Penicillin can also be applied locally, such as intra-mammary ducts, intra-uterine and intra-articular cavity injection to treat mastitis, endometritis and arthritis. In addition, some people in China are combined with streptomycin and injected into the postnatal prophylactic fish to prevent and control secondary infections.

Penicillin is also used for the treatment of enterococcal infectious pericarditis, tetanus and gas gangrene caused by Clostridium difficile, epidemic encephalomyelitis, listeriosis and so on. Penicillin is also used as the drug of choice during or after surgery to prevent inflammation.

Pharmacological Effect of Penicillin G Potassium.

Penicillin is a narrow-spectrum bactericidal antibiotic with strong antibacterial action. Penicillin on a variety of gram-positive bacteria (including streptococci, pneumococci, sensitive staphylococci and bacilli), some gram-negative cocci (including meningococci, gonococci), spirochetes and actinomycetes have a strong antimicrobial activity, the gram-positive bacilli including diphtheria bacilli, bacillus anthracis, and gram-positive anaerobic bacilli, such as tetanus bacilli, podococcus, etc. Sensitive; but the role of the gram-negative bacilli is very weak. Ineffective against Mycobacterium tuberculosis, rickettsiae, viruses, etc.

Penicillin is a bacteriostatic agent during bacterial reproduction, mainly by interfering with the synthesis of the bacterial cell wall to produce antibacterial effects.

It can inhibit the synthesis of mucopeptide, the basic component of the bacterial cell wall, resulting in cell wall defects, so that water penetrates into the bacterial cytoplasm, resulting in the swelling of the bacterium, deformation, and ultimately the death of cleavage. Since the cell wall mucopeptide content of gram-positive bacteria is higher than that of gram-negative bacteria, it has a stronger effect on the former. Human and animal cells do not have cell walls, so penicillin is almost non-toxic to them.

Caveat of  Bulk Penicillin G Potassium Powder.

Penicillin is stable under dry conditions, but decomposition is accelerated when it is wet, and it is extremely unstable in aqueous solution, so it is advisable to dissolve the preparation before use and use it up as soon as possible.

If it cannot be used up at one time, it can be temporarily stored in 4℃ refrigerator and used up within the same day to ensure the efficacy of the medicine and reduce allergic and other adverse reactions.

Penicillin is more stable in near-neutral (pH 6-7) solution, acidic or alkaline solution can accelerate its decomposition. It is best to dissolve it in water for injection or saline when applying, and it is also decomposed to a certain extent when dissolved in glucose.

Penicillin decomposes very quickly in alkaline solutions, and it is strictly forbidden to pair alkaline solutions (such as sodium bicarbonate) with it. Penicillin is decomposed or precipitated when it meets chlorpromazine hydrochloride and heavy metal salts.

When used in combination, attention should be paid to the contraindications and interactions with other drugs, such as penicillins and tetracyclines, chloramphenicol, macrolides, sulfonamides are antagonistic, and should not be used in combination.