Cefotaxime Sodium raw materials Cefotaxime Sodium Powder

CAS:59277-89-3

MF:C8H11N5O3

MW:225.2

EINECS:261-685-1

Specification: 99% min Cefotaxime Sodium Powder

Sample:Cefotaxime Sodium Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Cefotaxime Sodium Powder Usage and Synthesis.

Cefotaxime sodium is a commonly used carbapenem antibiotic, belongs to the third generation of semi-synthetic cephalosporins, the antibacterial spectrum is broader than cefuroxime, the role of gram-negative bacteria is stronger, the antibacterial spectrum includes haemophilic influenza bacillus, Escherichia coli, Escherichia coli, Salmonella Klebsiella spp. and Aspergillus exoticus, Neisseria spp. Staphylococcus, Pneumococcus, Streptococcus, Klebsiella and Salmonella spp. and other intestinal bacteria. Enterobacteriaceae and Salmonella.

Cefotaxime sodium has no antibacterial activity against Pseudomonas aeruginosa and alkali-producing bacilli, poor antibacterial activity against Staphylococcus aureus, strong activity against gram-positive cocci such as haemolytic Streptococcus, Streptococcus pneumoniae, and enterococci spp. (Enterococcus inguinalis, Enterobacter aerogenes) are resistant to this product.

Uses and functions of Cefotaxime Sodium.

The third generation of broad-spectrum cephalosporin antibiotics, strong bactericidal effect on both gram-negative and positive bacteria, especially on gram-negative bacteria, stable to β-lactamase, must be injected.

Clinically used for respiratory infections caused by sensitive bacteria, urinary tract infections, biliary tract and intestinal infections, skin and soft tissue infections, sepsis, burns and bone and joint infections, etc.

Mainly used for the treatment of respiratory system, urinary system, intestinal and biliary tract, skin and soft tissue, burns and bone and joint infections caused by sensitive bacteria.

Cefotaxime sodium can be clinically applied to pneumonia and other lower respiratory tract infections, urinary tract infections, meningitis, septicaemia, abdominal infections, pelvic infections, skin and soft tissue infections, reproductive tract infections, bone and joint infections caused by sensitive bacteria. Cefotaxime can be used as the drug of choice for paediatric meningitis.

Note of Cefotaxime Sodium.

1, cephalosporin allergy and a history of penicillin anaphylaxis or immediate reaction is prohibited.

2, Cefotaxime sodium 1.05g is equivalent to 1g of cefotaxime, each 1g of cefotaxime sodium content of about 2.2mmol (51mg). 1g of cefotaxime dissolved in 14ml of sterilised water for injection to form isotonic solution.

3.To prepare intramuscular injection, 0.5g, 1.0g or 2.0g of Chemicalbook's cefotaxime is added to 2ml, 3ml or 5ml of sterilised water for injection, respectively. For intravenous solutions, add at least 10-20 ml of sterilised water for injection to the above unspecified amount of cefotaxime sodium and inject slowly over 5-10 minutes.

For intravenous drip, dilute the intravenous solution again with appropriate solvent to 100-500 ml. Intramuscular injection dose exceeding 2 g should be injected at different sites.

Product Method of  Bulk Cefotaxime Sodium Powder.

8g of sodium bicarbonate was dissolved in 20ml of ethanol, 45.55g of 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]cephalosporin-3 slightly-4-carboxylic acid (cefotaxime) dissolved in 100 ml of distilled water was added successively to the solution, followed by the addition of 80rnl of ethanol and 4.5g of activated charcoal, and then after stirring for 5min, filtration was performed.

The filter cake was washed with ethanol and the filtrate was concentrated under reduced pressure to to, the residue was dissolved in: 100 ml of ethanol and then concentrated to dryness. The residue was dissolved in 100ml of methanol and poured into 2L of acetone. The resulting solution was stirred vigorously and filtered under reduced pressure, the solid was washed slightly first with acetone and then with ether and dried under vacuum to give 43.7 g of white sodium cefotaxime.

This cefotaxime sodium was hygroscopic in air and weighed 45.2 g after hygroscopy as a hydrate of cefotaxime sodium.